梗阻性黄疸患者中细胞因子对中性粒细胞的激活作用。
Neutrophil priming by cytokines in patients with obstructive jaundice.
作者信息
Jiang W G, Puntis M C, Hallett M B
机构信息
University Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
出版信息
HPB Surg. 1994;7(4):281-9. doi: 10.1155/1994/74202.
Patients with obstructive jaundice frequently suffer postoperative complications. We have investigated the relationship of obstructive jaundice to the neutrophil oxidase response and the "priming" of the response by the cytokines TNF alpha, interleukin-1 (IL-1), IL-6, and IL-8. On stimulation with f-met-leu-phe (fmlp), the respiratory burst in neutrophils from jaundiced patients was greatly increased compared with controls (p < 0.01), jaundiced patients having the highest respiratory burst levels were those with the poorest prognosis. Neutrophils from controls were primed by all the cytokines tested, whereas "jaundiced" cells were primed only by IL-1, and not by TNF alpha, IL-6, or IL-8, which in fact produced slight inhibition. We conclude that neutrophils from obstructive jaundiced patients have raised oxidative responses which may be due to "pre-priming" in vivo by cytokines, such as IL-6, IL-8, or TNF alpha. This exaggeration of the oxidative response in circulating neutrophils may contribute to the peri-operate complications of patients with obstructive jaundice.
梗阻性黄疸患者术后常出现并发症。我们研究了梗阻性黄疸与中性粒细胞氧化酶反应以及细胞因子肿瘤坏死因子α（TNFα）、白细胞介素-1（IL-1）、IL-6和IL-8对该反应的“预激”作用之间的关系。用甲酰甲硫氨酰-亮氨酰-苯丙氨酸（fmlp）刺激后，黄疸患者中性粒细胞的呼吸爆发与对照组相比显著增加（p < 0.01），呼吸爆发水平最高的黄疸患者预后最差。对照组的中性粒细胞被所有测试的细胞因子预激，而“黄疸”细胞仅被IL-1预激，不被TNFα、IL-6或IL-8预激，事实上这些因子还产生了轻微抑制作用。我们得出结论，梗阻性黄疸患者的中性粒细胞氧化反应增强，这可能是由于细胞因子如IL-6、IL-8或TNFα在体内的“预预激”作用。循环中性粒细胞氧化反应的这种过度增强可能导致梗阻性黄疸患者围手术期并发症的发生。
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