• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

左旋肉碱可减轻实验性胆道梗阻中的急性肺损伤。

L-carnitine reduces acute lung injury in experimental biliary obstruction.

作者信息

Kaya Ozgur, Koca Yavuz S, Barut İbrahim, Baspinar Sirin, Sabuncuoglu Mehmet Z

机构信息

Department of General Surgery, Medical Doctor of Yenimahalle State Hospital, Ankara, Turkey. E-mail.

出版信息

Saudi Med J. 2015 Sep;36(9):1046-52. doi: 10.15537/smj.2015.9.12206.

DOI:10.15537/smj.2015.9.12206
PMID:26318460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4613627/
Abstract

OBJECTIVES

To investigate the protective effects of L-carnitine (LC) on lungs in an experimental obstructive jaundice (OJ) model.

METHODS

This was conducted for 2 months between May 2011 and July 2011 at Suleyman Demirel University School of Medicine Experimental and Clinical Research Center, Isparta, Turkey. Thirty-eight Wistar-Albino rats with an average weight of 250-300 g were divided into 3 groups of control, OJ, and OJ + L-carnitine treatment (LCT). L-carnitine was injected intravenously into the tail vein at a dose of 50 mg/kg/day for 10 days to the LCT group. Animals were sacrificed 10 days later. Enzyme levels were measured in the lung tissue; malondialdehyde, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase. Tumor necrosis factor-alfa, interleukin 6 (IL-6), IL-8, and C-reactive protein levels were studied in plasma samples. Histopathological changes in the lungs were examined.

RESULTS

There was a decreased in GSH-Px, MPO, and IL-8 levels (p less than 0.05) in the LCT group. The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with LC (p less than 0.05).

CONCLUSION

L-carnitine has a protective effect against lung damage due to experimental obstructive jaundice, possibly by altering anticytokine and antioxidant activity, and by decreasing the neutrophil migration.

摘要

目的

研究左旋肉碱（LC）对实验性梗阻性黄疸（OJ）模型中肺脏的保护作用。

方法

本研究于2011年5月至2011年7月在土耳其伊斯帕尔塔市苏莱曼·德米雷尔大学医学院实验与临床研究中心进行，为期2个月。将38只平均体重为250 - 300克的Wistar - Albino大鼠分为对照组、OJ组和OJ + 左旋肉碱治疗（LCT）组。LCT组大鼠通过尾静脉以50毫克/千克/天的剂量静脉注射左旋肉碱，持续10天。10天后处死动物。测量肺组织中的酶水平；丙二醛、髓过氧化物酶（MPO）、谷胱甘肽过氧化物酶（GSH - Px）、过氧化氢酶和超氧化物歧化酶。研究血浆样本中肿瘤坏死因子 - α、白细胞介素6（IL - 6）、IL - 8和C反应蛋白水平。检查肺脏的组织病理学变化。

结果

LCT组中GSH - Px、MPO和IL - 8水平降低（p < 0.05）。组织病理学检查显示，左旋肉碱治疗后中性粒细胞浸润和水肿形成减少，肺实质破坏消失（p < 0.05）。

结论

左旋肉碱对实验性梗阻性黄疸所致的肺损伤具有保护作用，可能是通过改变抗细胞因子和抗氧化活性以及减少中性粒细胞迁移来实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/5d54ed83ba68/SaudiMedJ-36-1046-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/eaa218a4d678/SaudiMedJ-36-1046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/c9e5625565a7/SaudiMedJ-36-1046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/ff4888ade67b/SaudiMedJ-36-1046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/0aa9639ba4a0/SaudiMedJ-36-1046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/5d54ed83ba68/SaudiMedJ-36-1046-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/eaa218a4d678/SaudiMedJ-36-1046-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/c9e5625565a7/SaudiMedJ-36-1046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/ff4888ade67b/SaudiMedJ-36-1046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/0aa9639ba4a0/SaudiMedJ-36-1046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf67/4613627/5d54ed83ba68/SaudiMedJ-36-1046-g005.jpg

相似文献

1
L-carnitine reduces acute lung injury in experimental biliary obstruction.左旋肉碱可减轻实验性胆道梗阻中的急性肺损伤。
Saudi Med J. 2015 Sep;36(9):1046-52. doi: 10.15537/smj.2015.9.12206.
2
The effect of N-acetylcysteine on pulmonary lipid peroxidation and tissue damage.N-乙酰半胱氨酸对肺脂质过氧化和组织损伤的影响。
J Surg Res. 2005 Nov;129(1):38-45. doi: 10.1016/j.jss.2005.05.026.
3
Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats.左旋肉碱在预防四氯化碳诱导的大鼠急性肝损伤中的作用。
J Gastroenterol Hepatol. 2004 Mar;19(3):333-8. doi: 10.1111/j.1440-1746.2003.03291.x.
4
The protective effect of ellagic acid on lung damage caused by experimental obstructive jaundice model.鞣花酸对实验性梗阻性黄疸模型所致肺损伤的保护作用。
Acta Chir Belg. 2013 Jul-Aug;113(4):285-9. doi: 10.1080/00015458.2013.11680929.
5
[The effect of hydrogen on hemorrhagic shock induced acute lung injury in rats].[氢气对大鼠失血性休克诱导的急性肺损伤的影响]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Jun;25(6):347-50. doi: 10.3760/cma.j.issn.2095-4352.2013.06.008.
6
Protective effects of L-carnitine and alpha-lipoic acid in rats with adjuvant arthritis.左旋肉碱和α-硫辛酸对佐剂性关节炎大鼠的保护作用。
Pharmacol Res. 2007 Oct;56(4):303-10. doi: 10.1016/j.phrs.2007.07.008. Epub 2007 Aug 3.
7
L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death.左旋肉碱可改善甲氨蝶呤诱导的氧化性器官损伤并抑制白细胞死亡。
Cell Biol Toxicol. 2006 Jan;22(1):47-60. doi: 10.1007/s10565-006-0025-0.
8
Protective effects of L-carnitine on myoglobinuric acute renal failure in rats.左旋肉碱对大鼠肌红蛋白尿性急性肾衰竭的保护作用。
Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):119-24. doi: 10.1111/j.1440-1681.2006.04336.x.
9
Protective effect of Danning tablet on acute livery injury with cholestasis induced by α-naphthylisothiocyanate in rats.丹宁片对α-萘异硫氰酸酯诱导的大鼠急性胆汁淤积性肝损伤的保护作用。
J Ethnopharmacol. 2012 Mar 27;140(2):222-9. doi: 10.1016/j.jep.2011.12.047. Epub 2012 Jan 16.
10
Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction.葡萄籽提取物可减轻实验性胆道梗阻中的氧化应激和纤维化。
J Gastroenterol Hepatol. 2007 Jun;22(6):885-92. doi: 10.1111/j.1440-1746.2007.04875.x.

引用本文的文献

1
The effects of rose oil on liver damage in an experimental model of obstructive jaundice.玫瑰油对阻塞性黄疸实验模型中肝损伤的影响。
Ulus Travma Acil Cerrahi Derg. 2025 Jun;31(6):495-504. doi: 10.14744/tjtes.2025.96613.
2
L-carnitine protects the lung from radiation-induced damage in rats via the AMPK/SIRT1/TGF-1ß pathway.左旋肉碱通过 AMPK/SIRT1/TGF-β 途径保护大鼠肺免受辐射损伤。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):8043-8051. doi: 10.1007/s00210-024-03157-w. Epub 2024 May 22.
3
L-carnitine reduces acute lung injury via mitochondria modulation and inflammation control in pulmonary macrophages.

本文引用的文献

1
Combined effects of tauroursodeoxycholic Acid and glutamine on bacterial translocation in obstructive jaundiced rats:牛磺熊去氧胆酸和谷氨酰胺联合作用对梗阻性黄疸大鼠细菌易位的影响：
Balkan Med J. 2013 Dec;30(4):362-8. doi: 10.5152/balkanmedj.2013.7785. Epub 2013 Dec 1.
2
Red blood cells serve as intravascular carriers of myeloperoxidase.红细胞作为髓过氧化物酶的血管内载体。
J Mol Cell Cardiol. 2014 Sep;74:353-63. doi: 10.1016/j.yjmcc.2014.06.009. Epub 2014 Jun 26.
3
The diagnostic value of C-reactive protein in bacterial translocation in experimental biliary obstruction.
左旋肉碱通过调节肺巨噬细胞中线粒体和控制炎症减轻急性肺损伤。
Braz J Med Biol Res. 2023 Oct 20;56:e12830. doi: 10.1590/1414-431X2023e12830. eCollection 2023.
4
Dynamic Changes in the Microbiome and Mucosal Immune Microenvironment of the Lower Respiratory Tract by Influenza Virus Infection.流感病毒感染引起的下呼吸道微生物群和黏膜免疫微环境的动态变化
Front Microbiol. 2019 Nov 1;10:2491. doi: 10.3389/fmicb.2019.02491. eCollection 2019.
5
NLRP3 inflammasome activation in platelets in response to sepsis.脓毒症时血小板中NLRP3炎性小体的激活
Physiol Rep. 2019 May;7(9):e14073. doi: 10.14814/phy2.14073.
C反应蛋白在实验性胆道梗阻细菌移位中的诊断价值
Adv Clin Exp Med. 2014 Mar-Apr;23(2):197-203. doi: 10.17219/acem/37054.
4
Effects of sulfasalazine on lipid peroxidation and histologic liver damage in a rat model of obstructive jaundice and obstructive jaundice with lipopolysaccharide-induced sepsis.柳氮磺胺吡啶对阻塞性黄疸大鼠模型及脂多糖诱导脓毒症的阻塞性黄疸大鼠模型脂质过氧化和肝脏组织学损伤的影响。
Curr Ther Res Clin Exp. 2009 Aug;70(4):299-315. doi: 10.1016/j.curtheres.2009.08.005.
5
The protective effects of ketamine and propofol in obstructive jaundice: an experimental study.氯胺酮和丙泊酚在梗阻性黄疸中的保护作用：一项实验研究。
Bratisl Lek Listy. 2012;113(3):139-44. doi: 10.4149/bll_2012_034.
6
Cytokine response to portal endotoxaemia and neutrophil stimulation in obstructive jaundice.梗阻性黄疸时门静脉内毒素血症和中性粒细胞刺激的细胞因子反应。
Eur J Gastroenterol Hepatol. 2012 Jan;24(1):25-32. doi: 10.1097/MEG.0b013e32834b0dd3.
7
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.L-肉碱类似物在心脏代谢紊乱临床应用中的重要更新。
Vasc Health Risk Manag. 2011;7:169-76. doi: 10.2147/VHRM.S14356. Epub 2011 Mar 28.
8
The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats.左旋肉碱补充剂对乙醇诱导大鼠血清和中枢神经系统抗氧化能力的影响。
Metab Brain Dis. 2010 Dec;25(4):381-9. doi: 10.1007/s11011-010-9217-7. Epub 2010 Nov 12.
9
L-Carnitine protects plasma components against oxidative alterations.左旋肉碱可保护血浆成分免受氧化损伤。
Nutrition. 2011 Jun;27(6):693-9. doi: 10.1016/j.nut.2010.06.009. Epub 2010 Sep 24.
10
Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats.卡托普利和左旋肉碱对自发性高血压大鼠血压和心脏抗氧化酶基因表达的比较影响。
Eur J Pharmacol. 2010 Apr 25;632(1-3):65-72. doi: 10.1016/j.ejphar.2010.01.017. Epub 2010 Feb 1.