Gatsura V V, Gaevyĭ M D, Davidov E R, Pogorelyĭ V E, Pyzhnyĭ V O
Eksp Klin Farmakol. 1994 Mar-Apr;57(2):22-4.
Biotechnological cytochrome c, heme-tetradecapeptide (HTDP) and animal cytochrome c were studied for their effects on intact and brain ischemic rats. In the latter case, the compounds were administered before ischemia induction and 15 min after artery ligation. It was found that the cytochrome c preparations did not virtually affect the cerebral circulation in intact rats. In cerebral ischemia, the cytochrome C preparations increased circulation, showing their more profound effects in case of preadministration of the drugs. The dose-independent effects of HTDP may be associated with the higher transmembranous permeability and the saturation phenomenon of this compound.
研究了生物技术细胞色素c、血红素十四肽（HTDP）和动物细胞色素c对完整大鼠和脑缺血大鼠的影响。在后一种情况下，在诱导缺血前和动脉结扎后15分钟给予这些化合物。发现细胞色素c制剂实际上对完整大鼠的脑循环没有影响。在脑缺血时，细胞色素c制剂增加了循环，表明在预先给药的情况下其作用更为显著。HTDP的剂量非依赖性作用可能与其较高的跨膜通透性和该化合物的饱和现象有关。
