Kosmachev A B, Kosmacheva I M, Iankhotova M V, Kuleshov V I
Eksp Klin Farmakol. 1994 Mar-Apr;57(2):6-8.
The experiments to inhibit a tremor reaction induced by various cholinomimetics have established that DED50 of atropine and amedine is significantly indifferent when tremor is caused by pilocarpine, oxotremorine, and aceclidine while the activity of amedine is lower than that of atropine when ezerine, arecoline and galantamine are applied. The comparison of the findings with the data on the selectivity of the above M-cholinolytics leads to the conclusion that in in vivo experiments, the muscarinic agonists are able to show their selectivity against various subtypes of M-cholinoreceptors. The results of in vivo experiments are found to differ from the data on the in vitro selectivity of M-cholinomimetics in some cases.
抑制由各种拟胆碱药诱发的震颤反应的实验表明，当震颤由毛果芸香碱、氧化震颤素和醋甲胆碱引起时，阿托品和阿美丁的半数有效剂量（DED50）无显著差异，而当使用毒扁豆碱、槟榔碱和加兰他敏时，阿美丁的活性低于阿托品。将这些结果与上述M胆碱能阻滞剂的选择性数据进行比较得出结论，在体内实验中，毒蕈碱激动剂能够对不同亚型的M胆碱受体表现出选择性。在某些情况下，发现体内实验结果与M拟胆碱药的体外选择性数据有所不同。
