Koskela H, Tukiainen H, Kononoff A, Pekkarinen H
Department of Respiratory Medicine, Kuopio University Hospital, Finland.
Chest. 1994 Jun;105(6):1728-31. doi: 10.1378/chest.105.6.1728.
To assess the effect of subfreezing temperature and wind on lung function in asthmatic patients, an exposure to subfreezing temperature at rest, a moderate exercise challenge at subfreezing temperature, and a similar exercise challenge at room temperature were performed in 19 stable asthmatic subjects in an environmental chamber with an artificial wind. The mean maximal falls in FEV1 were 5.3, 11.7, and 4.8 percent, respectively. The two challenges at subfreezing temperature caused statistically significant changes in FEV1, but the exercise challenge at room temperature had no effect. A large variation in the sensitivity to cold was found. The time courses of the responses varied between the challenges, suggesting at least partially different mechanisms. The results indicate that even moderate exercise can cause severe bronchoconstriction in certain stable asthmatic subjects at climatic conditions similar to the Scandinavian winter. The importance of reflex mechanisms causing bronchoconstriction in physiologic conditions is discussed.
为评估亚冰点温度和风力对哮喘患者肺功能的影响，在一个带有人工风的环境舱中，对19名病情稳定的哮喘受试者进行了如下测试：静息状态下暴露于亚冰点温度、亚冰点温度下的适度运动激发试验以及室温下的类似运动激发试验。第一秒用力呼气量（FEV1）的平均最大降幅分别为5.3%、11.7%和4.8%。亚冰点温度下的两项激发试验导致FEV1出现具有统计学意义的变化，但室温下的运动激发试验没有影响。研究发现对寒冷的敏感性存在很大差异。不同激发试验的反应时间进程各不相同，这表明机制至少部分不同。结果表明，在类似于斯堪的纳维亚冬季的气候条件下，即使是适度运动也可能在某些病情稳定的哮喘受试者中引起严重的支气管收缩。本文还讨论了在生理条件下引起支气管收缩的反射机制的重要性。
