Riesbeck K, Sigvardsson M, Leanderson T, Forsgren A
Department of Medical Microbiology, Lund University, Malmö General Hospital, Sweden.
J Immunol. 1994 Jul 1;153(1):343-52.
In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-gamma production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1 alpha, IL-2 and its receptor, IFN-gamma, IL-3, IL-4, granulocyte-macrophage/CSF, TNF-alpha, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1) and AP-1 were also found to be increased by ciprofloxacin. Thus, ciprofloxacin interferes with a regulative pathway common to several cytokines.
除了具有抗菌特性外，某些抗生素还是生物反应调节剂。例如，氟化4-喹诺酮环丙沙星可上调体外刺激的外周血淋巴细胞（PBLs）中白细胞介素-2（IL-2）和γ-干扰素（IFN-γ）的产生。在本研究中，环丙沙星被证明可增加白细胞介素-1α（IL-1α）、IL-2及其受体、IFN-γ、IL-3、IL-4、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、肿瘤坏死因子-α（TNF-α）和淋巴毒素的mRNA水平。在用不同的T细胞有丝分裂原和同种异体抗原进行研究时，发现环丙沙星对IL-2产生的上调与刺激方式无关。转录活性分析表明，环丙沙星可增强IL-2基因的诱导。还发现环丙沙星可增加活化T细胞核因子（NF-AT-1）和活化蛋白-1（AP-1）的浓度。因此，环丙沙星干扰了几种细胞因子共有的调节途径。
