Hachen H J, Krucker V
Eur Urol. 1977;3(4):237-40. doi: 10.1159/000472104.
A comparative clinical trial with oral and intravenous baclofen (Lioresal) was performed in a homogeneous group of 70 male patients, hospitalized with traumatic paraplegia. The dosage was 75 mg daily by mouth over a period of 10 days or 20 mg daily i.v. for 2 days. Drug efficacy was evaluated both clinically (residual urine; facilitation of micturition) and urodynamically (integrated cystosphincterometry, sphincter electromyography and micturition cysto-urethrograms). During oral therapy there were no significant changes in any of the studied parameters. Intravenous administration, on the contrary, proved highly effective and better tolerated.
对70名因外伤性截瘫住院的男性患者组成的同质群体进行了口服和静脉注射巴氯芬（力奥来素）的对比临床试验。剂量为口服每日75毫克，持续10天，或静脉注射每日20毫克，持续2天。通过临床（残余尿量；排尿促进）和尿动力学（膀胱括约肌测压、括约肌肌电图和排尿膀胱尿道造影）评估药物疗效。口服治疗期间，任何研究参数均无显著变化。相反，静脉给药证明非常有效且耐受性更好。
