Pettinato G, Manivel J C, Gould E W, Albores-Saavedra J
Department of Pathology, University of Naples Federico II, Italy.
Am J Clin Pathol. 1994 Jun;101(6):714-8. doi: 10.1093/ajcp/101.6.714.
Two cases of fibromatosis of the breast, characterized by a proliferation of spindle cells containing intracytoplasmic, spherical, eosinophilic inclusion bodies, are reported. The light and electron microscopic features, as well as the immunohistochemical features, are indistinguishable from those found in infantile digital fibromatosis. The proliferating spindle cells are characterized as myofibroblasts, whereas the inclusion bodies show an immunohistochemically nonreactive, hollow-like pattern with peripheral reactivity for actin filaments. This lesion, observed for the first time in the breast, expands the number of extradigital inclusion body fibromatoses.
本文报告了两例乳腺纤维瘤病，其特征为含有胞浆内球形嗜酸性包涵体的梭形细胞增生。光镜、电镜及免疫组化特征与婴儿指部纤维瘤病所见难以区分。增生的梭形细胞被鉴定为肌成纤维细胞，而包涵体显示免疫组化无反应性的中空样模式，周边有肌动蛋白丝反应性。此病变首次在乳腺中观察到，增加了指外包涵体纤维瘤病的病例数。
