Morozova M S, Goncharova V N, Astakhova T M, Zaĭtseva T S, Manuilova I A
Akush Ginekol (Mosk). 1994(1):14-6.
Prostaglandins E2 and F2 alpha were measured in decidual tissue of women after spontaneous abortions at pregnancy terms 8 to 10 weeks and after abortions induced by sulprostone, a synthetic prostaglandin E2 analog, at pregnancy term 4-5 weeks. Women in whom pregnancy was terminated surgically at relevant periods were controls. Prostaglandin E2 concentration was found to be 5 times higher and that of prostaglandin F2 alpha 40 times higher in women with spontaneous abortions than in surgical abortion. In sulprostone-induced abortion prostaglandin concentrations in decidual tissue were the same as in controls. These data indicate that a drastic increase of prostaglandin levels in spontaneous abortion is not only a result of myometrial contractions or decidual tissue rejection, but an important component in the chain of events leading to miscarriage.
对妊娠8至10周自然流产的女性以及妊娠4至5周使用合成前列腺素E2类似物硫前列酮引产的女性的蜕膜组织中的前列腺素E2和F2α进行了测量。在相关时期接受手术终止妊娠的女性作为对照。结果发现，自然流产女性的前列腺素E2浓度比手术流产女性高5倍，前列腺素F2α浓度高40倍。在硫前列酮引产中，蜕膜组织中的前列腺素浓度与对照相同。这些数据表明，自然流产中前列腺素水平的急剧升高不仅是子宫肌层收缩或蜕膜组织排斥的结果，而且是导致流产的一系列事件中的一个重要因素。
