Koller W C, Busenbark K, Miner K
Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314.
Ann Neurol. 1994 Jun;35(6):717-23. doi: 10.1002/ana.410350613.
We examined 678 essential tremor patients in specialty, university, and private practice clinics. The mean age of patients was 65.2 years with a similar number of men and women. Six percent of patients were left-handed. A positive family history of tremor was reported in more than 60% of patients. Alcohol ingestion was reported to decrease tremor in 74% of patients who were cognizant of the effect of alcohol on tremor. Mean age at tremor onset was 45.3 years. An earlier onset of tremor was observed in those patients having a positive family history of tremor. Tremor affected the hands in 90% of patients, head in 50%, voice in 30%, and legs and chin in 15%. Functional disability was common and impairment at work occurred in 18%. Propranolol and primidone were the most frequently used drugs and were effective in 40% of patients. Six and one-tenth percent of essential tremor patients had concomitant Parkinson's disease, 6.9% had a coexisting dystonia, and 1.8% had myoclonus. It is concluded that the frequency of Parkinson's disease in essential tremor is more than would be reported in the general population and that other movement disorders are infrequently observed in essential tremor.
我们在专科诊所、大学诊所和私人诊所对678例特发性震颤患者进行了检查。患者的平均年龄为65.2岁，男女数量相近。6%的患者为左利手。超过60%的患者报告有震颤的家族史。据报告，74%知晓酒精对震颤有影响的患者饮酒后震颤减轻。震颤的平均发病年龄为45.3岁。有震颤家族史的患者震颤发病较早。90%的患者震颤累及双手，50%累及头部，30%累及声音，15%累及腿部和下巴。功能障碍很常见，18%的患者工作受到影响。普萘洛尔和扑米酮是最常用的药物，对40%的患者有效。6.1%的特发性震颤患者合并帕金森病，6.9%合并肌张力障碍，1.8%合并肌阵挛。结论是，特发性震颤患者中帕金森病的发生率高于一般人群报告的发生率，且特发性震颤患者很少观察到其他运动障碍。
