Massey E W, Paulson G W
South Med J. 1985 Mar;78(3):316-7.
We evaluated four patients with an initial and predominant voice tremor. All were referred for evaluation for suspected parkinsonism, though vocal tremor was the only symptom. These three women and one man ranged in age from 37 to 59 years. Neurologic evaluation and laryngeal examination were unremarkable. No signs of parkinsonism were present. All patients had a family history of tremor, though in only one family was vocal tremor the sole manifestation. Tremor was suppressed by alcohol ingestion in all patients and with whisper in two. Duration of tremor before evaluation ranged from eight months to six years. Visual representation of tremor was obtained in three, with frequencies ranging from 4 to 10 cps. Three patients responded to treatment with propranolol (Inderal), and one did well with voice training. Follow-up was six months to ten years. Although previous cases of essential vocal tremor with concurrent tremor elsewhere have been noted, only six cases of isolated voice tremor had been reported and response to therapy was not mentioned. Essential tremor may also be isolated to the head, chin, and hands.
我们评估了4例以声音震颤为首发且主要症状的患者。尽管声音震颤是唯一症状，但所有患者均因疑似帕金森病而被转诊进行评估。这3名女性和1名男性年龄在37至59岁之间。神经学评估和喉部检查均无异常。未发现帕金森病体征。所有患者都有震颤家族史，但只有一个家族中声音震颤是唯一表现。所有患者饮酒后震颤均减轻，2例患者轻声说话时震颤减轻。评估前震颤持续时间为8个月至6年。3例患者获得了震颤的视觉表现，频率范围为4至10次/秒。3例患者对普萘洛尔（心得安）治疗有反应，1例患者通过嗓音训练效果良好。随访时间为6个月至10年。尽管之前已注意到原发性声音震颤合并其他部位震颤的病例，但仅报告了6例孤立性声音震颤病例，且未提及治疗反应。特发性震颤也可能仅局限于头部、下巴和手部。
