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人IgA1免疫球蛋白的完整共价结构

Complete covalent structure of a human IgA1 immunoglobulin.

作者信息

Liu Y S, Low T L, Infante A, Putnam F W

出版信息

Science. 1976 Sep 10;193(4257):1017-20. doi: 10.1126/science.821146.

DOI:10.1126/science.821146
PMID:821146
Abstract

The complete covalent structure has been determined for a human myeloma IgA1 immunoglobulin. This protein has unique features in the amino acid sequence and disulfide bridge structure of the variable (V) and constant (C) regions of both the alpha heavy and the lambda light chains, and in the number and loci of oligosaccharides. Whereas C region domains of heavy chains have evolved independently over eons, recent isotypic variations have occured in lambda light chains and possibly in alpha heavy chains.

摘要

已确定一种人类骨髓瘤IgA1免疫球蛋白的完整共价结构。该蛋白在α重链和λ轻链的可变（V）区和恒定（C）区的氨基酸序列、二硫键结构以及寡糖的数量和位点方面具有独特特征。重链的C区结构域历经漫长岁月独立进化，而λ轻链以及可能的α重链近期出现了同种型变异。

相似文献

1
Complete covalent structure of a human IgA1 immunoglobulin.人IgA1免疫球蛋白的完整共价结构
Science. 1976 Sep 10;193(4257):1017-20. doi: 10.1126/science.821146.
2
Similarities of the light chains and the variable regions of the heavy chains of the IgG2 lambda and IgA1 lambda myeloma proteins from a single patient.来自一名患者的IgG2λ和IgA1λ骨髓瘤蛋白的轻链及重链可变区的相似性。
J Immunol. 1974 Mar;112(3):871-6.
3
Distribution and association of heavy and light chain variable region subgroups among human IgA immunoglobulins.人IgA免疫球蛋白中重链和轻链可变区亚组的分布及关联
J Immunol. 1975 Feb;114(2 Pt 1):678-81.
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[Rule of antibody structure. Primary structure of a human monoclonal IgAl-immunoglobulin (myeloma protein Tro). VI. Amino acid sequence of the L-chain, lambda-type, subgroup II].[抗体结构规则。人单克隆IgA1免疫球蛋白（骨髓瘤蛋白Tro）的一级结构。VI。λ型II亚组L链的氨基酸序列]
Hoppe Seylers Z Physiol Chem. 1979 Dec;360(12):1903-18.
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Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda.含碳水化合物的缺失型人λ型免疫球蛋白轻链的一级结构：蛋白质Smλ
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4559-63. doi: 10.1073/pnas.72.11.4559.
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Sequence relationships among the variable regions of immunoglobulin heavy chains from various mammalian species.来自各种哺乳动物物种的免疫球蛋白重链可变区之间的序列关系。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2052-5. doi: 10.1073/pnas.69.8.2052.
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Partial amino acid sequence of an IgA2 human immunoglobulin heavy chain.人IgA2免疫球蛋白重链的部分氨基酸序列
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Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype.A2m(2)同种异型的人IgA2免疫球蛋白α2重链的完整氨基酸序列。
Proc Natl Acad Sci U S A. 1978 Feb;75(2):966-9. doi: 10.1073/pnas.75.2.966.
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Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.具有抗半抗原活性的小鼠骨髓瘤蛋白重链（α链）可变区的氨基酸序列。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1123-7. doi: 10.1073/pnas.71.4.1123.
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Complete amino acid sequence of a mouse immunoglobulin alpha chain (MOPC 511).小鼠免疫球蛋白α链（MOPC 511）的完整氨基酸序列
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4909-13. doi: 10.1073/pnas.77.8.4909.

引用本文的文献

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Immunoglobulin A Antibodies: From Protection to Harmful Roles.免疫球蛋白A抗体：从保护作用到有害作用
Immunol Rev. 2024 Nov;328(1):171-191. doi: 10.1111/imr.13424. Epub 2024 Nov 23.
2
Possible palindromes in immunoglobulin heavy-chain genes: Their role in membrane attachment.可能存在于免疫球蛋白重链基因中的回文序列：它们在膜附着中的作用。
Immunogenetics. 1978 Dec;7(1):1-12. doi: 10.1007/BF01843981.
3
Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.
N-乙酰半乳糖胺特异性蜗牛凝集素识别 IgA1 铰链区的半乳糖缺乏型 O-聚糖：比较结合研究。
Biochemistry. 2010 Jul 13;49(27):5671-82. doi: 10.1021/bi9019498.
4
Evidence for a site-specific fucosylation of N-linked oligosaccharide of immunoglobulin A1 from normal human serum.正常人血清免疫球蛋白A1的N-连接寡糖存在位点特异性岩藻糖基化的证据。
Glycoconj J. 1998 Oct;15(10):995-1000. doi: 10.1023/a:1006989910120.
5
Analysis of the specificity of bacterial immunoglobulin A (IgA) proteases by a comparative study of ape serum IgAs as substrates.通过将猿血清IgA作为底物进行比较研究来分析细菌免疫球蛋白A（IgA）蛋白酶的特异性。
Infect Immun. 1996 Mar;64(3):933-7. doi: 10.1128/iai.64.3.933-937.1996.
6
The structure and function of proline-rich regions in proteins.蛋白质中富含脯氨酸区域的结构与功能。
Biochem J. 1994 Jan 15;297 ( Pt 2)(Pt 2):249-60. doi: 10.1042/bj2970249.
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Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD.人IgDδ重链第一恒定区结构域和铰链区的氨基酸序列。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6168-72. doi: 10.1073/pnas.78.10.6168.
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The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.HLA - DR抗原重链的氨基酸序列与基因结构：与免疫球蛋白的同源性
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6013-7. doi: 10.1073/pnas.79.19.6013.
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Complete amino acid sequence of the delta heavy chain of human immunoglobulin D.人免疫球蛋白Dδ重链的完整氨基酸序列
Proc Natl Acad Sci U S A. 1982 May;79(9):2850-4. doi: 10.1073/pnas.79.9.2850.
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Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function.人免疫球蛋白D的Fc区一级结构：对进化起源和生物学功能的启示
Proc Natl Acad Sci U S A. 1981 Jan;78(1):504-8. doi: 10.1073/pnas.78.1.504.