Roessler W, Steinbach P, Nicolai H, Hofstaedter F, Wieland W F
Abteilung für Urologie, Krankenhaus St. Josef, Regensburg, Deutschland.
Urol Res. 1993;21(4):273-7. doi: 10.1007/BF00307710.
Between September 1990 and July 1991, we treated 17 patients with renal-cell carcinoma by radical nephrectomy and two patients with urothelial carcinoma of the kidney pelvis by ureteronephrectomy. Immediately after nephrectomy, perfusion of the kidneys with cold HTK solution was performed and the organs were kept in hypothermia of 8 degrees C. The tumor-free parenchyma of the kidneys was treated 4 h later with shock waves of different energy levels in an experimental shock-wave system (Siemens Company, Erlangen). Light microscopy and examinations by scanning laser microscopy were performed after treatment. High-energy shock waves (HESW) produce significant changes in the tubulary and blood-vessel system of the viable human kidney, depending on the energy applied. Although our model is limited by hypothermia of the explanted kidneys, the effects of shock waves on the organs can be studied. Our model is suitable for testing the effects of different lithotriptors on the human kidney.
1990年9月至1991年7月期间，我们对17例肾细胞癌患者实施了根治性肾切除术，并对2例肾盂尿路上皮癌患者实施了输尿管肾切除术。肾切除术后立即用冷HTK溶液对肾脏进行灌注，并将器官置于8摄氏度的低温环境中。4小时后，在一个实验性冲击波系统（西门子公司，埃尔朗根）中，用不同能量水平的冲击波对肾脏的无肿瘤实质进行处理。处理后进行光学显微镜检查和扫描激光显微镜检查。高能冲击波（HESW）会根据施加的能量，对存活的人体肾脏的肾小管和血管系统产生显著变化。虽然我们的模型受限于离体肾脏的低温状态，但仍可研究冲击波对器官的影响。我们的模型适用于测试不同碎石机对人体肾脏的影响。
