Newman R, Hackett R, Senior D, Brock K, Feldman J, Sosnowski J, Finlayson B
Urology. 1987 Feb;29(2):194-200. doi: 10.1016/0090-4295(87)90152-x.
The introduction of extracorporeal shock wave lithotripsy (ESWL) has provided an avenue for dealing with many urinary stones noninvasively. The margin of safety for the kidney during shock wave administration is largely undefined. A pilot study was performed where six kidneys in five female mongrel dogs were shocked. Group A kidneys were given 1,776, 4,500, 6,000, or 8,000 shocks, respectively, at 18-24 kV. Group B kidneys received 1,600 and 8,000 shocks (18-24 kV). The number of shocks per electrode ranged from 500 to 4,538 and averaged 2,490. The dogs were sacrificed forty-eight to seventy-two hours (Group A) or twenty-eight to thirty-two days (Group B) post-treatment. Modest damage (hematoma and/or interstitial hemorrhage) was noted in all kidneys. Evidence of permanent change (fibrosis) was noted in both Group B kidneys. Complete necrosis of the kidney was not seen after administration of 8,000 shocks. These preliminary data indicate that lithotripsy can, in some circumstances, produce renal damage in the canine model.
体外冲击波碎石术（ESWL）的引入为无创处理许多泌尿系统结石提供了一条途径。在冲击波治疗过程中，肾脏的安全界限很大程度上尚不明确。进行了一项初步研究，对5只雌性杂种犬的6个肾脏进行了冲击。A组肾脏分别在18 - 24 kV下接受1776、4500、6000或8000次冲击。B组肾脏接受1600次和8000次冲击（18 - 24 kV）。每个电极的冲击次数在500至4538次之间，平均为2490次。在治疗后48至72小时（A组）或28至32天（B组）处死这些犬。在所有肾脏中均观察到轻度损伤（血肿和/或间质出血）。在B组的两个肾脏中均观察到永久性改变（纤维化）的证据。在给予8000次冲击后未见到肾脏完全坏死。这些初步数据表明，在某些情况下，碎石术可在犬模型中造成肾脏损伤。
