Nielsen I K, Engdahl E, Larsen T
Department of Obstetrics and Gynecology, Glostrup University Hospital, Denmark.
Acta Obstet Gynecol Scand. 1993 Oct;72(7):556-9. doi: 10.3109/00016349309058163.
In a double-blind stratificated, placebo controlled study the efficacy and safety of a single oral dose of ofloxanin (Tarivid) (400 mg) in preventing postabortal pelvic inflammatory disease (P-PID) in women with induced first-trimester abortions were assessed. The tablets were given 1 1/2-2 h before the abortion, and the women were followed one month after the operation. Group I consisted of 308 with previous PID. Ofloxacin tablets were given to 149 women and 159 women received placebo tablets. In the ofloxacin group 20 women (13.4%) and in the placebo group 27 women (17%) developed P-PID, a non-significant difference (p = 0.39). Group II consisted of 765 women without a history of PID. Ofloxacin tablets were given to 376 women and 389 women received placebo tablets. Thirty-five women (9.3%) in the ofloxacin group and 46 women (11.9%) in the placebo group developed P-PID, a non-significant difference (p = 0.26). A single oral dose of ofloxacin (400 mg) did not reduce the incidence of P-PID either among women with previous PID or among women without previous PID.
在一项双盲分层、安慰剂对照研究中，评估了单次口服一剂氧氟沙星（泰利必妥）（400毫克）对预防早孕人工流产妇女流产后盆腔炎（P-PID）的疗效和安全性。在流产前1.5至2小时给药，术后对妇女随访一个月。第一组由308名有盆腔炎病史的妇女组成。149名妇女服用氧氟沙星片，159名妇女服用安慰剂片。氧氟沙星组有20名妇女（13.4%）发生P-PID，安慰剂组有27名妇女（17%）发生P-PID，差异无统计学意义（p=0.39）。第二组由765名无盆腔炎病史的妇女组成。376名妇女服用氧氟沙星片，389名妇女服用安慰剂片。氧氟沙星组有35名妇女（9.3%）发生P-PID，安慰剂组有46名妇女（11.9%）发生P-PID，差异无统计学意义（p=0.26）。单次口服一剂氧氟沙星（400毫克）对有盆腔炎病史的妇女或无盆腔炎病史的妇女均未降低P-PID的发生率。
