Davidson E S, Finch J F, Schenk S
Department of Psychology, Texas A&M University, College Station 77843-4235.
Addict Behav. 1993 Jul-Aug;18(4):445-53. doi: 10.1016/0306-4603(93)90062-e.
Eighty psychology students were administered a short self-report questionnaire that probed their initial and most recent experiences with cocaine. Most of the subjects were relatively inexperienced with cocaine; only five had used the drug more than 40 times. Measures of Global Positive and Global Negative responses to cocaine use were obtained. There was substantial variability in the response to cocaine on both the positive and negative effects scales, although there was no relationship between the magnitude of these self-reported effects of cocaine. The initial Global Positive (but not Global Negative) scores were correlated with latency to next use of cocaine and with lifetime use of the drug, suggesting that abuse potential of the drug is related to magnitude of initial positive effect. These data suggest that studies on predisposing factors in cocaine abuse should examine the basis for the variability in initial response to cocaine.
80名心理学专业学生接受了一份简短的自我报告问卷调查，该问卷探究了他们最初和最近使用可卡因的经历。大多数受试者相对缺乏使用可卡因的经验；只有5人使用该药物超过40次。获得了对使用可卡因的总体积极和总体消极反应的测量结果。在积极和消极影响量表上，对可卡因的反应存在很大差异，尽管这些自我报告的可卡因影响程度之间没有关联。最初的总体积极（而非总体消极）得分与下次使用可卡因的潜伏期以及该药物的终身使用情况相关，这表明该药物的滥用可能性与最初积极影响的程度有关。这些数据表明，关于可卡因滥用易感因素的研究应考察对可卡因初始反应变异性的基础。
