抗坏血酸2-硫酸盐在恒河猴中缺乏抗坏血病活性。

Lack of antiscorbutic activity of ascorbate 2-sulfate in the rhesus monkey.

作者信息

Machlin L J, Garcia F, Kuenzig W, Richter C B, Spiegel H E, Brin M

出版信息

Am J Clin Nutr. 1976 Aug;29(8):825-31. doi: 10.1093/ajcn/29.8.825.

DOI:10.1093/ajcn/29.8.825

Abstract

Oral administration of 10 mg per kilogram of body weight of ascorbic acid (AA) completely prevented development of scurvy in juvenile rhesus monkey (Mucaca mulata) fed an AA-free liquid diet. The same dose cured scurvy when injected intramuscularly. An equimolar dose of ascorbic acid 2-sulfate (AA-2-S) did not prevent or cure scurvy. Neither AA nor AA-2-S altered serum cholesterol. AA but not AA-2-S reduced serum triglyceride. A case of scurvy in an AA-2-S treated monkey is described in detail.

摘要

给幼年恒河猴（猕猴）喂食不含抗坏血酸（AA）的流质饮食，口服每千克体重10毫克的抗坏血酸可完全预防坏血病的发生。相同剂量肌肉注射可治愈坏血病。等摩尔剂量的2-硫酸抗坏血酸（AA-2-S）不能预防或治愈坏血病。AA和AA-2-S均未改变血清胆固醇水平。AA可降低血清甘油三酯水平，但AA-2-S不能。详细描述了一只接受AA-2-S治疗的猴子患坏血病的病例。