White T T, Heimbach D M
Am J Surg. 1976 Aug;132(2):270-5. doi: 10.1016/0002-9610(76)90059-3.
Surgical treatment has been used in those patients with hemorrhagic pancreatitis who deteriorate after several days of intensive medical therapy, or in those patients in whom the diagnosis cannot be established early in the course of treatment. Initial therapy consisted of: cholecystostomy or T-tube drainage in those patients who have gallstones, jaundice, or distended biliary tree; gastrostomy for prolonged gastric decompression; jejunostomy to provide a portal for enteroalimentation; and appropriate soft rubber drainage of the pancreatic bed as a simple, safe, and effective means of treating severe hemorrhagic pancreatitis. Adjunctive daily hyperalimentation and later sequestrectomy of necrotic pancreatic tissue provided a mortality of 20 per cent and complete rehabilitation of sixteen of thirty patients so treated. Delaying the initial approach to necrotic pancreas allows precise delineation of necrotic material so that sequestrectomy, leaving behind normal pancreas, can be carried out to avoid exocrine and endocrine deficiencies after the acute episode has passed.
对于那些在强化内科治疗数天后病情恶化的出血性胰腺炎患者,或在治疗过程早期无法确诊的患者,可采用手术治疗。初始治疗包括:对有胆结石、黄疸或胆管扩张的患者进行胆囊造口术或T管引流;进行胃造口术以延长胃肠减压;进行空肠造口术以提供肠内营养的途径;以及对胰腺床进行适当的软橡胶引流,作为治疗严重出血性胰腺炎的一种简单、安全且有效的方法。辅助性每日胃肠外营养以及随后对坏死胰腺组织进行坏死组织切除术,使死亡率达到20%,接受治疗的30名患者中有16名完全康复。延迟对坏死胰腺的初始处理,可精确界定坏死物质,从而能够在急性发作过后进行坏死组织切除术,保留正常胰腺,避免外分泌和内分泌功能不足。