Goodgame J T, Fischer J E
Ann Surg. 1977 Nov;186(5):651-8. doi: 10.1097/00000658-197711000-00018.
Clinical characteristics of 46 cases of acute pancreatitis treated with total parenteral nutrition were examined. Hyperalimentation may be used in these severely ill patients with minimal technical or metabolic morbidity. This method of nutritional support can maintain patients with nonfunctional gastrointestinal tracts for several months. Catheter-related sepsis was more common than expected early in the course of acute pancreatitis but caused minimal morbidity. The incidence of catheter-related sepsis late in disease was minor. Hyperalimentation had little if any effect on the pathophysiology of acute pancreatitis as judged by the overall mortality and the incidence and severity of the complications of acute respiratory failure and acute renal failure. It is not clear that parenteral hyperalimentation alters the course of acute pancreatitis but it is a useful adjunct for nutritional support in this illness.
对46例接受全胃肠外营养治疗的急性胰腺炎患者的临床特征进行了检查。对于这些重症患者，可采用高营养支持，其技术或代谢并发症最少。这种营养支持方法可使胃肠道无功能的患者维持数月。在急性胰腺炎病程早期，导管相关败血症比预期更为常见，但导致的发病率最低。疾病后期导管相关败血症的发生率较低。从总体死亡率以及急性呼吸衰竭和急性肾衰竭并发症的发生率和严重程度判断，高营养对急性胰腺炎的病理生理学几乎没有影响。尚不清楚胃肠外高营养是否会改变急性胰腺炎的病程，但它是这种疾病营养支持的一种有用辅助手段。
