Berg A T
Department of Pediatrics, Yale School of Medicine, New Haven, Conn. 06510.
Am J Dis Child. 1993 Oct;147(10):1101-3. doi: 10.1001/archpedi.1993.02160340087020.
Pediatricians are frequently taught that a rapid rise in temperature is responsible for causing a febrile seizure; yet there are no clinical data to support this hypothesis. The few experimental data are based on hyperthermia-induced seizures in animals and are of no clear relevance to naturally occurring fevers and accompanying seizures. Further, the experimental findings are not consistent across studies. By contrast, there is substantial evidence indicating that the height of temperature plays a role in eliciting a febrile seizure. Although febrile seizures are now recognized as benign and, in general, a disorder that should not be treated with chronic anticonvulsant therapy, an understanding of how fevers lead to febrile seizures may be useful for evaluating the appropriateness and efficacy of treatments that involve intermittent therapy given at the time of fever.
儿科医生经常被教导说体温快速上升会导致热性惊厥；然而，没有临床数据支持这一假设。少数实验数据是基于动物热诱导惊厥得出的，与自然发生的发热及伴随的惊厥并无明确关联。此外，各研究的实验结果并不一致。相比之下，有大量证据表明体温高度在引发热性惊厥中起作用。尽管热性惊厥现在被认为是良性的，一般来说是一种不应采用慢性抗惊厥治疗的疾病，但了解发热如何导致热性惊厥可能有助于评估发热时进行间歇性治疗的适宜性和疗效。
