Baker D G, Bruss M L, Gershwin L J
Department of Veterinary Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616.
Am J Vet Res. 1993 Aug;54(8):1294-8.
Pepsinogen and protein concentrations were determined in blood samples, collected from the left gastroepiploic artery and vein, and in abomasal lymph from 15 steers naturally infected with Ostertagia ostertagi and 4 uninfected steers. In steers with type-1 ostertagiosis, the concentration gradient between the mucosal interstitium and the blood alone could account for higher than normal serum pepsinogen concentrations. High interstitial pepsinogen concentrations may have resulted from increased epithelial permeability or increased pepsinogen production and secretion. However, in steers with type-2 ostertagiosis, the concentration gradient could not entirely account for the high serum pepsinogen concentrations, suggesting that capillary permeability or surface area may have been altered. Lymphatic uptake contributed pepsinogen to the blood in all infected steers.
对15头自然感染奥斯特他线虫的阉牛和4头未感染的阉牛，采集其胃网膜左动脉和静脉的血样以及皱胃淋巴液，测定其中的胃蛋白酶原和蛋白质浓度。在患1型奥斯特他线虫病的阉牛中，仅黏膜间质与血液之间的浓度梯度就可解释血清胃蛋白酶原浓度高于正常水平的原因。较高的间质胃蛋白酶原浓度可能是由于上皮通透性增加或胃蛋白酶原产生和分泌增加所致。然而，在患2型奥斯特他线虫病的阉牛中，该浓度梯度并不能完全解释血清胃蛋白酶原浓度升高的原因，这表明毛细血管通透性或表面积可能发生了改变。在所有感染的阉牛中，淋巴吸收都将胃蛋白酶原输送到血液中。
