Gupta R W, Joseph C K, Foster D A
Institute for Biomolecular Structure and Function, Hunter College, City University of New York, New York 10021.
Biochem Biophys Res Commun. 1993 Oct 15;196(1):320-7. doi: 10.1006/bbrc.1993.2251.
The tumor promoter okadaic acid is a potent inhibitor of the serine/threonine protein phosphatases 1 and 2A. Addition of okadaic acid to v-Src-transformed BALB/c 3T3 cells reverted them to a flat morphology, increased fibronectin levels in the extracellular matrix, reduced saturation density, and inhibited the formation of colonies in soft agar. The ability of v-Src-transformed cells to proliferate in low serum was also inhibited by okadaic acid. These data implicate serine/threonine phosphatases in v-Src-induced transformation.
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