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1
Effects of okadaic acid on cell growth, anchorage-independent growth, and co-cultures of normal (KMS-6), immortalized (KMST-6), and neoplastically transformed (KMST-6T and KMST-6/RAS) human fibroblasts.冈田酸对正常（KMS-6）、永生化（KMST-6）和肿瘤转化（KMST-6T和KMST-6/RAS）人成纤维细胞的细胞生长、不依赖贴壁生长及共培养的影响。
J Cancer Res Clin Oncol. 1996;122(4):249-53. doi: 10.1007/BF01209654.
2
Tautomycin: an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach.互隔交链孢酚单甲醚：一种蛋白磷酸酶1和2A的抑制剂，但在小鼠皮肤和大鼠腺胃中并非肿瘤促进剂。
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3
Neoplastic transformation and characterization of human fibroblasts by treatment with 60Co gamma rays and the human c-Ha-ras oncogene.用60Coγ射线和人c-Ha-ras癌基因处理对人成纤维细胞进行肿瘤转化及特性研究
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4
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.蛋白磷酸酶抑制剂冈田酸诱导培养的视网膜母细胞瘤细胞凋亡
J Cancer Res Clin Oncol. 1995;121(12):729-38. doi: 10.1007/BF01213319.
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Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.正常人成纤维细胞的多步骤致癌作用。经钴-60γ射线反复处理永生化的人成纤维细胞被Ha-ras癌基因转化为致瘤细胞。
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本文引用的文献

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Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors.用蛋白磷酸酶抑制剂处理叙利亚仓鼠胚胎细胞诱导肿瘤进展
Cancer Res. 1993 Apr 15;53(8):1777-82.
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v-Src-induced transformation is inhibited by okadaic acid.
Biochem Biophys Res Commun. 1993 Oct 15;196(1):320-7. doi: 10.1006/bbrc.1993.2251.
3
Neoplastic transformation and characterization of human fibroblasts by treatment with 60Co gamma rays and the human c-Ha-ras oncogene.用60Coγ射线和人c-Ha-ras癌基因处理对人成纤维细胞进行肿瘤转化及特性研究
In Vitro Cell Dev Biol Anim. 1993 Oct;29A(10):763-7. doi: 10.1007/BF02634342.
4
Inhibition of cell communication between Balb/c 3T3 cells by tumor promoters and protection by cAMP.肿瘤启动子对Balb/c 3T3细胞间细胞通讯的抑制作用及环磷酸腺苷的保护作用。
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Science. 1967 Sep 22;157(3795):1443-4. doi: 10.1126/science.157.3795.1443.
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Colony size, cell density and nature of the tumor promoter are critical variables in expression of a transformed phenotype (focus formation) in co-cultures of UV-TDTx and C3H10T1/2 cells.在紫外线照射的经化学致癌剂处理的细胞（UV-TDTx）与C3H10T1/2细胞的共培养中，集落大小、细胞密度和肿瘤启动子的性质是转化表型（灶形成）表达的关键变量。
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Multi-step neoplastic transformation of normal human fibroblasts by Co-60 gamma rays and Ha-ras oncogenes.
Mutat Res. 1988 Jun;199(2):415-23. doi: 10.1016/0027-5107(88)90218-7.
8
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.冈田酸：一种额外的非佛波醇-12-十四烷酸酯-13-乙酸酯型肿瘤促进剂。
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1768-71. doi: 10.1073/pnas.85.6.1768.
9
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.海洋海绵毒素冈田酸对蛋白磷酸酶的抑制作用。特异性和动力学。
Biochem J. 1988 Nov 15;256(1):283-90. doi: 10.1042/bj2560283.
10
Flat reversion by okadaic acid of raf and ret-II transformants.冈田酸对raf和ret-II转化体的扁平回复
Proc Natl Acad Sci U S A. 1989 Dec;86(24):9946-50. doi: 10.1073/pnas.86.24.9946.

冈田酸对正常（KMS-6）、永生化（KMST-6）和肿瘤转化（KMST-6T和KMST-6/RAS）人成纤维细胞的细胞生长、不依赖贴壁生长及共培养的影响。

Effects of okadaic acid on cell growth, anchorage-independent growth, and co-cultures of normal (KMS-6), immortalized (KMST-6), and neoplastically transformed (KMST-6T and KMST-6/RAS) human fibroblasts.

作者信息

Jahan I, Iijima M, Kondo T, Namba M

机构信息

Department of Cell Biology, Institute of Cellular and Molecular Biology, Okayama Univeristy Medical School, Japan.

出版信息

J Cancer Res Clin Oncol. 1996;122(4):249-53. doi: 10.1007/BF01209654.

DOI:10.1007/BF01209654
PMID:8601579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12201053/
Abstract

The effects of okadaic acid (OA) on normal human (KMS-6), its immortalized (KMST-6) and neoplastically transformed (KMST-6T and KMST-6/RAS) cells were investigated as a model of two stage carcinogenesis. The presence of OA inhibited cell growth of the normal and immortalized cells but not that of the neoplastic KMST-6T cells. In contrast, cell growth of the other neoplastic KMST-6/RAS cells transformed with the Ha-ras oncogene was inhibited by OA. OA enhanced colony formation of KMST-6T cells in soft agar, but it suppressed that of KMST-6/RAS cells. Co-cultures of KMST-6T cells with normal KMS-6 cells showed an increase in focus formation of KMST-6T cells in the presence of OA, whereas focus formation of KMST-6/RAS cells decreased. These results indicate that OA has growth-promoting effects on certain types of transformed human cells.

摘要

作为两阶段致癌模型，研究了冈田酸（OA）对正常人细胞（KMS - 6）、其永生化细胞（KMST - 6）和肿瘤转化细胞（KMST - 6T和KMST - 6/RAS）的影响。OA的存在抑制了正常细胞和永生化细胞的生长，但对肿瘤性KMST - 6T细胞的生长没有抑制作用。相反，用Ha - ras癌基因转化的另一种肿瘤性KMST - 6/RAS细胞的生长受到OA的抑制。OA增强了KMST - 6T细胞在软琼脂中的集落形成，但抑制了KMST - 6/RAS细胞的集落形成。在OA存在的情况下，KMST - 6T细胞与正常KMS - 6细胞的共培养显示KMST - 6T细胞的灶形成增加，而KMST - 6/RAS细胞的灶形成减少。这些结果表明，OA对某些类型的转化人细胞具有促生长作用。