Yamada S, Murawaki Y, Kawasaki H
Second Department of Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan.
Biochem Pharmacol. 1993 Sep 14;46(6):1081-5. doi: 10.1016/0006-2952(93)90674-l.
The preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats was examined by histological and biochemical analysis. Acetaminophen at a dose of 750 mg/kg was administered to male Wistar rats with or without pretreatment with 50 mg/kg of gomisin A. Gomisin A inhibited not only the elevation of serum aminotransferase activity and hepatic lipoperoxides content, characteristic of acetaminophen administration, but also the appearance of histological changes such as degeneration and necrosis of hepatocytes. However, gomisin A did not affect the decrease in liver glutathione content. These results suggest that gomisin A protects the liver from injury after administration of acetaminophen through the suppression of lipid peroxidation.
通过组织学和生化分析，研究了五味子果实中的木脂素成分戈米辛A对大鼠对乙酰氨基酚诱导的肝毒性的预防作用。给雄性Wistar大鼠给予750mg/kg的对乙酰氨基酚，同时或不预先给予50mg/kg的戈米辛A。戈米辛A不仅抑制了血清转氨酶活性升高和肝脂质过氧化物含量增加（这是对乙酰氨基酚给药的特征），还抑制了肝细胞变性和坏死等组织学变化的出现。然而，戈米辛A并不影响肝脏谷胱甘肽含量的降低。这些结果表明，戈米辛A通过抑制脂质过氧化作用，保护肝脏免受对乙酰氨基酚给药后的损伤。
