Petkov V D, Kehayov R A, Mosharrof A H, Petkov V V, Getova D, Lazarova M B, Vaglenova J
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Arzneimittelforschung. 1993 Aug;43(8):822-8.
The effects of cytidine diphosphate choline (CDP-choline, CAS 987-78-0) on learning and memory in rats with memory deficits were examined using behavioral methods of active avoidance with punishment reinforcement (shuttle-box), passive avoidance with punishment reinforcement (step-through and step-down), and active avoidance with positive (alimentary) reinforcement (staircase-maze). In the majority of experiments CDP-choline was applied orally at doses of 10-50 or 100 mg/kg daily for 7 days before the training session. The experiments were carried out on young-adult (aged 5 months) and old (aged 22 months) rats and on rats with a low capability for retention of learned behavior. Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy. Memory deficits were also induced in rats offspring of dams that had been exposed to alcohol during pregnancy and lactation. The results suggest that CDP-choline acts as a memory-enhancing drug and that its effect is particularly pronounced in animals with memory deficits.
采用带有惩罚强化的主动回避（穿梭箱）、带有惩罚强化的被动回避（穿梭箱和阶梯式穿梭箱）以及带有正向（食物）强化的主动回避（阶梯迷宫）等行为学方法，研究了胞苷二磷酸胆碱（CDP-胆碱，CAS 987-78-0）对记忆缺陷大鼠学习和记忆的影响。在大多数实验中，在训练前7天，每天以10 - 50或100 mg/kg的剂量口服CDP-胆碱。实验在年轻成年（5个月龄）和老年（22个月龄）大鼠以及学习行为保持能力较低的大鼠身上进行。通过毒蕈碱型胆碱能受体拮抗剂东莨菪碱（在年轻和老年大鼠及小鼠中）、α2-肾上腺素能受体激动剂可乐定、电惊厥休克和缺氧诱导记忆缺陷。在孕期和哺乳期暴露于酒精的母鼠所生的大鼠后代中也诱导出记忆缺陷。结果表明，CDP-胆碱作为一种增强记忆的药物，其作用在有记忆缺陷的动物中尤为明显。
