Markovits P, Lévy S, Nocentini A, Velizarov A, Sabharwal P S, Benda P
C R Acad Hebd Seances Acad Sci D. 1976 Jun 14;282(22):2015-20.
Hamster embryo brain cells exposed in vitro for 24 hrs. to benzo (a) pyrene and then subcultivated. undergo a morphological transformation. After several passages, transformed cells are capable in most cases of inducing tumors of a special type through intraocular or intracerebral grafting. Histological characterisation of these tumors suggests that they are of glial type. Untreated control brain cells subcultivated for one year, keep their normal characteristics and do not induce tumors when grafted in Hamster.
仓鼠胚胎脑细胞在体外暴露于苯并(a)芘24小时后进行传代培养，会发生形态转化。经过几次传代后，大多数情况下，转化细胞能够通过眼内或脑内移植诱导出一种特殊类型的肿瘤。这些肿瘤的组织学特征表明它们是神经胶质类型的。未经处理的对照脑细胞传代培养一年，保持其正常特征，移植到仓鼠体内时不会诱导肿瘤。
