Kokolis N, Ploumis T, Smokovitis A
Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
Alcohol. 1993 Sep-Oct;10(5):375-9. doi: 10.1016/0741-8329(93)90023-h.
Plasminogen activator activity (PAA), tissue-type PA (t-PA) antigen level, plasminogen activator inhibition (PAI), and plasmin inhibition (PI) showed no sex-dependent differences in the stomach of the rat. Chronic ethanol consumption induced an increase of PAA and t-PA antigen and a decrease of PAI (urokinase-type PA [u-PAI]) and PI in the body and pyloric region (PI only in the pyloric region). PAA increase and u-PAI decrease in the pyloric region were greater in the male than in the female. Orchidectomy, but not ovariectomy, induced effects similar to those of ethanol. The effects of orchidectomy and chronic ethanol consumption on gastric PAA, t-PA antigen, and PAI were additive. An increased PAA and decreased PAI or PI in the stomach in cases of hypogonadism, particularly if this deficiency is combined with chronic ethanol consumption, might influence the susceptibility to pathological conditions related to or affected by the local fibrinolytic activity (PAA, PAI, or PI).
在大鼠胃部，纤溶酶原激活物活性（PAA）、组织型纤溶酶原激活物（t-PA）抗原水平、纤溶酶原激活物抑制物（PAI）以及纤溶酶抑制物（PI）均未表现出性别依赖性差异。长期摄入乙醇会导致大鼠体内及幽门区域的PAA和t-PA抗原增加，PAI（尿激酶型纤溶酶原激活物抑制物[u-PAI]）及PI减少（仅幽门区域的PI减少）。幽门区域PAA的增加及u-PAI的减少在雄性大鼠中比雌性大鼠更为显著。睾丸切除而非卵巢切除会产生与乙醇类似的效应。睾丸切除和长期摄入乙醇对胃PAA、t-PA抗原及PAI的影响具有叠加性。性腺功能减退时胃部PAA增加、PAI或PI减少，尤其是当这种功能缺陷与长期摄入乙醇同时存在时，可能会影响机体对与局部纤溶活性（PAA、PAI或PI）相关或受其影响的病理状况的易感性。
