Kokolis N A
Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Greece.
Haemostasis. 1990;20(4):233-40. doi: 10.1159/000216133.
The effect of unilateral or bilateral orchidectomy on tissue plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) was studied in the rat. Orchidectomy was performed in young or adult rats. Unilateral orchidectomy affected only PI in the lungs and brain, 1, 2 and 3 months after orchidectomy was performed in adult rats. Bilateral orchidectomy performed in young or adult rats affected one or more of the parameters studied in one or more of the key organs (brain, lungs, kidneys, heart, aorta), in most cases only 2 and 3 months after orchidectomy. Therefore, the effect of orchidectomy on tissue PAA, PAI or PI was variable and dependent on the extent of the orchidectomy (unilateral or bilateral), the age of the animal at orchidectomy, the time after orchidectomy, and the organ.
在大鼠中研究了单侧或双侧睾丸切除术对组织纤溶酶原激活物活性（PAA）、纤溶酶原激活物抑制物（PAI）和纤溶酶抑制物（PI）的影响。对年轻或成年大鼠进行睾丸切除术。成年大鼠单侧睾丸切除术后1、2和3个月，仅影响肺和脑中的PI。对年轻或成年大鼠进行双侧睾丸切除术，会影响一个或多个关键器官（脑、肺、肾、心脏、主动脉）中研究的一个或多个参数，在大多数情况下，仅在睾丸切除术后2和3个月出现这种情况。因此，睾丸切除术对组织PAA、PAI或PI的影响是可变的，并且取决于睾丸切除术的范围（单侧或双侧）、进行睾丸切除术时动物的年龄、睾丸切除术后的时间以及器官。
