大鼠主动脉、心脏和大脑中纤溶酶原激活物活性、组织型纤溶酶原激活物抗原、纤溶酶原激活物抑制物及纤溶酶抑制物的昼夜变化受内毒素、阿司匹林或内毒素加阿司匹林的影响。

Circadian variations of plasminogen activator activity, tissue-type plasminogen activator antigen, plasminogen activator inhibition and plasmin inhibition in rat aorta, heart and brain are influenced by endotoxin or aspirin or endotoxin plus aspirin.

作者信息

Kokolis N, Rekkas C, Tsandarliotou M, Smokovitis A

机构信息

Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Greece.

出版信息

Haemostasis. 1995 May-Jun;25(3):106-13. doi: 10.1159/000217149.

DOI:10.1159/000217149

PMID:7607578

Abstract

The effect of aspirin or endotoxin or aspirin plus endotoxin on the circadian variations of plasminogen activator activity (PAA), tissue-type plasminogen activator (t-PA) antigen level, plasminogen activator inhibition (PAI) and plasmin inhibition (PI) in aorta, heart and brain of the rat was studied. In aorta the circadian variations of PAA, t-PA antigen and tissue-type PAI (t-PAI) were blunted by endotoxin, while the circadian variation of PI was reversed; t-PAI variation was blunted by aspirin plus endotoxin, while PI variation was reversed. Various disturbances of the circadian variations of PAA, t-PA antigen, PAI or PI in heart and brain were also observed. In conclusion, the circadian variations of fibrinolytic parameters in key organs are influenced by aspirin or endotoxin or aspirin plus endotoxin in a varying way or degree depending on the treatment, the parameter studied or the organ.

摘要

研究了阿司匹林、内毒素或阿司匹林加内毒素对大鼠主动脉、心脏和大脑中纤溶酶原激活物活性（PAA）、组织型纤溶酶原激活物（t-PA）抗原水平、纤溶酶原激活物抑制（PAI）和纤溶酶抑制（PI）昼夜变化的影响。在内主动脉中，内毒素使PAA、t-PA抗原和组织型PAI（t-PAI）的昼夜变化减弱，而PI的昼夜变化则相反；阿司匹林加内毒素使t-PAI变化减弱，而PI变化则相反。在心脏和大脑中也观察到PAA、t-PA抗原、PAI或PI昼夜变化的各种紊乱。总之，关键器官中纤溶参数的昼夜变化受到阿司匹林、内毒素或阿司匹林加内毒素的影响，其影响方式或程度因治疗方法、所研究的参数或器官而异。