Smokovitis A, Kokolis N, Ploumis T
Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
Alcohol. 1991 Jan-Feb;8(1):17-20. doi: 10.1016/0741-8329(91)91152-r.
In the normal stomach of male rats marked differences in plasminogen activator activity (PAA) and plasmin inhibition (PI), but not in plasminogen activator inhibition (PAI), were noted among cardiac area, body and pyloric region. Chronic ethanol consumption (for 15 or 30 days) at the concentration of 6% or 12% in the drinking water induced an increase in PAA in the pyloric region and the body of the stomach (the higher concentration after 15 days and both concentrations after 30 days). The response was time- and dose-dependent. At the cardiac area no change of PAA was noted. Ethanol at both concentrations induced after 30 days a decreased PAI in the pyloric region and the body of the stomach, which was expressed against u-PA, but not against t-PA. A decreased PI was noted at both concentrations of ethanol after 30 days only in the pyloric region. Therefore, changes in PAA, PAI and PI after chronic ethanol consumption were dependent on the concentration, the period of the consumption and the area along the gastric wall.
在雄性大鼠的正常胃中，在心区、胃体和幽门区观察到纤溶酶原激活物活性（PAA）和纤溶酶抑制（PI）存在显著差异，但纤溶酶原激活物抑制（PAI）无差异。在饮用水中以6%或12%的浓度长期摄入乙醇（15天或30天）会导致幽门区和胃体的PAA增加（15天后较高浓度以及30天后两种浓度均有增加）。这种反应具有时间和剂量依赖性。在心区未观察到PAA的变化。两种浓度的乙醇在30天后均导致幽门区和胃体的PAI降低，这是相对于尿激酶型纤溶酶原激活物（u-PA）而言，而非相对于组织型纤溶酶原激活物（t-PA）。仅在30天后，两种浓度的乙醇均导致幽门区的PI降低。因此，长期摄入乙醇后PAA、PAI和PI的变化取决于浓度、摄入时间以及胃壁的不同区域。
