Smokovitis A, Kokolis N, Taitzoglou I
Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
Haemostasis. 1991;21(5):305-12. doi: 10.1159/000216241.
Plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) have been studied with spectrophotometric methods in extracts of human, bovine, ovine and rat kidneys of both sexes. In all species studied, renal PAA (cortex or medulla) was higher in females than in males. The PAA was also higher in the medulla than in the cortex in all species and both sexes. The PAA was due to both types of plasminogen activator; tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). In the human kidney (cortex or medulla) the measurement of t-PA antigen showed that t-PA is higher in females than in males; t-PA is also higher in the medulla than in the cortex in both sexes. The PAI showed the opposite pattern in all species studied; it was lower in females than in males. It was also lower in the medulla than in the cortex. PAI-1 was identified in the human kidney. Sex-related differences in renal PAA or PAI almost disappeared after bilateral orchidectomy in rats. PI showed no sex or regional differences in the species studied. Sex-related differences in renal PAA and PAI in man and various animal species might be of physiological or pathophysiological importance.
已采用分光光度法对人类、牛、羊和大鼠两性的肾脏提取物中的纤溶酶原激活物活性（PAA）、纤溶酶原激活物抑制物（PAI）和纤溶酶抑制物（PI）进行了研究。在所有研究的物种中，雌性肾脏（皮质或髓质）的PAA均高于雄性。在所有物种的两性中，髓质中的PAA也高于皮质。PAA是由两种类型的纤溶酶原激活物引起的；组织型纤溶酶原激活物（t-PA）和尿激酶型纤溶酶原激活物（u-PA）。在人类肾脏（皮质或髓质）中，t-PA抗原的测量显示，女性的t-PA高于男性；在两性中，髓质中的t-PA也高于皮质。在所有研究的物种中，PAI呈现相反的模式；女性低于男性。在髓质中也低于皮质。在人类肾脏中鉴定出了PAI-1。大鼠双侧睾丸切除术后，肾脏PAA或PAI的性别相关差异几乎消失。在所研究的物种中，PI没有性别或区域差异。人类和各种动物物种肾脏中PAA和PAI的性别相关差异可能具有生理或病理生理意义。
