Riddell S R, Gilbert M J, Greenberg P D
Fred Hutchinson Cancer Research Center, Seattle.
Curr Opin Immunol. 1993 Aug;5(4):484-91. doi: 10.1016/0952-7915(93)90027-p.
The development of CD8+ cytotoxic T cell responses to viral pathogens is crucial for the prompt resolution of acute infections and for the control of viruses which persist in the host. Thus, cytomegalovirus often causes life threatening disease in immunosuppressed humans who fail to develop or maintain CD8+ cytotoxic T cells. Similarly, the loss of CD8+ cytotoxic T cell responses to HIV correlates with the development of AIDS. Recent investigations in the immunobiology of cytomegalovirus and HIV have resulted in the application of immunotherapeutic strategies designed to reconstitute or augment deficient CD8+ cytotoxic T cell responses to these human pathogens.
CD8 + 细胞毒性T细胞对病毒病原体的反应对于急性感染的迅速消退以及对宿主中持续存在的病毒的控制至关重要。因此，巨细胞病毒常常在无法产生或维持CD8 + 细胞毒性T细胞的免疫抑制人类中引发危及生命的疾病。同样，对HIV的CD8 + 细胞毒性T细胞反应丧失与艾滋病的发展相关。最近对巨细胞病毒和HIV免疫生物学的研究导致了免疫治疗策略的应用，这些策略旨在重建或增强对这些人类病原体的缺陷CD8 + 细胞毒性T细胞反应。
