Birx D L, Redfield R R
Department of Retroviral Research, Walter Reed Army Institute of Research, Washington D.C. 20307-5100.
Curr Opin Immunol. 1993 Aug;5(4):600-7. doi: 10.1016/0952-7915(93)90044-s.
The immune response against HIV does not result in complete viral clearance. Recent interventions have focused on novel strategies to modify human anti-HIV immunity. Active vaccination of patients with HIV infection (vaccine therapy) safely alters the immune repertoire against HIV. This unique approach will provide insight into the immunoregulatory consequences of HIV-specific innate and adaptive immune responses, and hopefully define the immunological Achilles heel of HIV. Once defined, researchers, aided by current biotechnological techniques, can rationally design future vaccines and immune based therapeutic products.
针对HIV的免疫反应并不能实现病毒的完全清除。近期的干预措施聚焦于改变人类抗HIV免疫的新策略。对HIV感染患者进行主动免疫接种（疫苗疗法）可安全地改变针对HIV的免疫库。这种独特的方法将深入了解HIV特异性固有免疫和适应性免疫反应的免疫调节后果，并有望确定HIV的免疫弱点。一旦确定，研究人员借助当前的生物技术可合理设计未来的疫苗和基于免疫的治疗产品。
