Heino J
Department of Medical Biochemistry, University of Turku, Finland.
Ann Med. 1993 Aug;25(4):335-42. doi: 10.3109/07853899309147294.
The integrins are a large family of cell adhesion receptors, involved in cell-cell and cell-matrix interactions. At present, 20 different integrin heterodimers are known. Integrins participate in a complex apparatus anchoring cells to their surroundings and transducting signals into the cells. These signals regulate many important aspects of cell behaviour, including growth, differentiation, and phenotype. This is an overview of the molecular and cellular biology of the integrin-type extracellular matrix receptors. Integrins may play a central role in the healing process of tissue injuries, and in many diseases, especially in human cancer.
整合素是一大类细胞黏附受体家族，参与细胞间和细胞与基质的相互作用。目前，已知有20种不同的整合素异二聚体。整合素参与一个复杂的机制，将细胞锚定到周围环境并将信号转导到细胞内。这些信号调节细胞行为的许多重要方面，包括生长、分化和表型。本文是整合素型细胞外基质受体的分子和细胞生物学概述。整合素可能在组织损伤的愈合过程以及许多疾病中发挥核心作用，尤其是在人类癌症中。
