Nyman M T, Paavolainen P, Lindholm T S
Department of Clinical Sciences, Tampere University, Finland.
Arch Orthop Trauma Surg. 1993;112(5):228-31. doi: 10.1007/BF00451880.
Eighty-eight rats underwent intramedullary pin fixation and fracture of both tibiae. Half of the animals were given clodronate 50 mg/kg s.c. weekly. Clodronate treatment did not affect the growth of fibrocartilage or the endochondral and membranous new bone formation. The regaining of tensile load capacity of fractured bone remained unaffected by the drug. Calluses were remodeled to lamellar bone in both groups. However, although the total area invaded by mineralized tissue in callus remained unaffected by the drug, the areas of hematopoietic bone marrow tissue within mineralized callus were observed to be markedly smaller in clodronate-treated animals than in controls. The calluses in the clodronate group were significantly heavier and contained more calcium at 2 months after fracture than those in the controls.
88只大鼠接受了双胫骨的髓内针固定和骨折手术。一半的动物每周皮下注射50mg/kg氯膦酸盐。氯膦酸盐治疗不影响纤维软骨的生长以及软骨内和膜内新骨形成。骨折骨的拉伸负荷能力的恢复不受该药物影响。两组的骨痂均重塑为板层骨。然而，尽管药物对骨痂中矿化组织侵入的总面积没有影响，但观察到氯膦酸盐治疗组动物矿化骨痂内的造血骨髓组织面积明显小于对照组。骨折后2个月，氯膦酸盐组的骨痂明显更重且含钙量更多。
