乳铁蛋白在体内调节肿瘤坏死因子α和白细胞介素6的释放。
Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.
作者信息
Machnicki M, Zimecki M, Zagulski T
机构信息
Laboratory of Immunobiology, Polish Academy of Sciences, Wroclaw.
出版信息
Int J Exp Pathol. 1993 Oct;74(5):433-9.
Abstract
The effects of bovine lactoferrin on the serum cytokine levels, induced by lipopolysaccharide (LPS) in mice, are described. Bovine lactoferrin (BLF) introduced intravenously, 24 hours before i.v. injection of 50 micrograms of LPS, significantly lowered the serum concentration of TNF-alpha. Doses of BLF lower than 100 micrograms as well as pretreatment of mice with BLF on days 6-2 or 12-2 hours before LPS challenge, were not effective. Moreover, BLF induces by itself a relatively high level of IL-6, peaking at 1 hour following injection. Pretreatment of LPS-injected mice with BLF causes, in addition, a small but statistically significant drop in IL-6 level. Human albumin, used as a control protein, did not cause any changes in the cytokine levels. The data reported herein provide a satisfactory explanation with regard to preventive activity of LF in infection.
摘要
描述了牛乳铁蛋白对小鼠体内脂多糖（LPS）诱导的血清细胞因子水平的影响。在静脉注射50微克LPS前24小时静脉注射牛乳铁蛋白（BLF），可显著降低血清肿瘤坏死因子-α（TNF-α）浓度。低于100微克的BLF剂量以及在LPS攻击前6 - 2天或12 - 2小时用BLF预处理小鼠均无效。此外，BLF自身可诱导相对较高水平的白细胞介素-6（IL-6），在注射后1小时达到峰值。用BLF预处理注射LPS的小鼠，还会使IL-6水平出现小幅但具有统计学意义的下降。用作对照蛋白的人白蛋白未引起细胞因子水平的任何变化。本文报道的数据为乳铁蛋白在感染中的预防活性提供了令人满意的解释。
相似文献
1
Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.乳铁蛋白在体内调节肿瘤坏死因子α和白细胞介素6的释放。
Int J Exp Pathol. 1993 Oct;74(5):433-9.
2
Lactoferrin lowers serum interleukin 6 and tumor necrosis factor alpha levels in mice subjected to surgery.乳铁蛋白可降低接受手术小鼠的血清白细胞介素6和肿瘤坏死因子α水平。
Arch Immunol Ther Exp (Warsz). 1998;46(2):97-104.
3
[Regulation of interleukin 6 (IL-6) and TNF-alpha through lactoferrin in mice].
Postepy Hig Med Dosw. 1995;49(1):53-7.
4
Bovine lactoferrin decreases histopathological changes in the liver and regulates cytokine production by splenocytes of obstructive jaundiced rats.牛乳铁蛋白可减轻梗阻性黄疸大鼠肝脏的组织病理学变化，并调节脾细胞的细胞因子产生。
Inflamm Res. 2003 Jun;52(7):305-10. doi: 10.1007/s00011-003-1178-4.
5
6
7
Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individuals.健康个体口服含牛乳铁蛋白营养制剂的免疫调节作用。
Arch Immunol Ther Exp (Warsz). 1998;46(4):231-40.
8
Recombinant human lactoferrin has preventive effects on lipopolysaccharide-induced preterm delivery and production of inflammatory cytokines in mice.重组人乳铁蛋白对脂多糖诱导的小鼠早产和炎性细胞因子产生具有预防作用。
J Perinat Med. 2005;33(4):320-3. doi: 10.1515/JPM.2005.057.
9
Bovine lactoferrin ingestion protects against inflammation via IL-11 induction in the small intestine of mice with hepatitis.牛乳铁蛋白摄入通过诱导小肠内白细胞介素-11 的产生来保护肝炎小鼠免受炎症的侵害。
Br J Nutr. 2014 May 28;111(10):1801-10. doi: 10.1017/S0007114513004315. Epub 2014 Jan 28.
10
Dietary lactoferrin does not prevent dextran sulfate sodium induced murine intestinal lymphocyte death.膳食乳铁蛋白不能预防葡聚糖硫酸钠诱导的小鼠肠道淋巴细胞死亡。
Exp Biol Med (Maywood). 2008 Sep;233(9):1099-108. doi: 10.3181/0802-RM-53. Epub 2008 Jun 5.
引用本文的文献
1
The Multifaceted Functions of Lactoferrin in Antimicrobial Defense and Inflammation.乳铁蛋白在抗菌防御和炎症中的多方面功能
Biomolecules. 2025 Aug 16;15(8):1174. doi: 10.3390/biom15081174.
2
Liposomal Lactoferrin Reduces Brain Neuroinflammation in Rats and Alleviates Jetlag and Improves Sleep Quality After Long-Haul Travel.脂质体乳铁蛋白可减轻大鼠脑部神经炎症，缓解长途旅行后的时差反应并改善睡眠质量。
NeuroSci. 2025 Mar 1;6(1):19. doi: 10.3390/neurosci6010019.
3
Lactoferrins in Their Interactions with Molecular Targets: A Structure-Based Overview.乳铁蛋白与分子靶点的相互作用：基于结构的概述
Pharmaceuticals (Basel). 2024 Mar 20;17(3):398. doi: 10.3390/ph17030398.
4
Lactoferrin as a Human Genome "Guardian"-An Overall Point of View.乳铁蛋白作为人类基因组的“守护者”-全面观点。
Int J Mol Sci. 2022 May 8;23(9):5248. doi: 10.3390/ijms23095248.
5
Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems.乳铁蛋白在超重相关女性生育问题中的抑制作用。
Nutrients. 2022 Feb 22;14(5):938. doi: 10.3390/nu14050938.
6
Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19.天然生物活性分子：治疗和控制 COVID-19 的另一种方法。
Int J Mol Sci. 2021 Nov 23;22(23):12638. doi: 10.3390/ijms222312638.
7
Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain.牛乳铁蛋白对新生大鼠缺氧缺血性脑损伤的剂量依赖性神经保护作用。
Nutrients. 2021 Oct 29;13(11):3880. doi: 10.3390/nu13113880.
8
A Review on Lactoferrin and Central Nervous System Diseases.乳铁蛋白与中枢神经系统疾病研究进展
Cells. 2021 Jul 17;10(7):1810. doi: 10.3390/cells10071810.
9
The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm.乳铁蛋白降低 SARS-CoV-2 诱导的细胞因子风暴的潜力。
Int Immunopharmacol. 2021 Jun;95:107571. doi: 10.1016/j.intimp.2021.107571. Epub 2021 Mar 12.
10
Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro.乳铁蛋白对体外 SARS-CoV-2 感染的保护作用。
Nutrients. 2021 Jan 23;13(2):328. doi: 10.3390/nu13020328.
本文引用的文献
1
[Preparation and properties of lactosiderophilin (lactotransferrin) of human milk].[人乳乳铁蛋白（乳运铁蛋白）的制备及性质]
Biochim Biophys Acta. 1960 Dec 18;45:413-21. doi: 10.1016/0006-3002(60)91478-5.
2
Modulation of classical C3 convertase of complement by tear lactoferrin.泪液乳铁蛋白对补体经典C3转化酶的调节作用。
Immunology. 1982 Oct;47(2):263-70.
3
Plasma lactoferrin reflects granulocyte activation in vivo.血浆乳铁蛋白反映体内粒细胞的激活情况。
Blood. 1983 May;61(5):885-8.
4
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.用于细胞生长和存活的快速比色测定法：应用于增殖和细胞毒性测定。
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. doi: 10.1016/0022-1759(83)90303-4.
5
Binding of C-reactive protein to chromatin and nucleosome core particles. A possible physiological role of C-reactive protein.C反应蛋白与染色质及核小体核心颗粒的结合。C反应蛋白的一种可能生理作用。
J Biol Chem. 1984 Jun 10;259(11):7311-6.
6
The involvement of lactoferrin in the hyposideremia of acute inflammation.乳铁蛋白在急性炎症性低铁血症中的作用。
J Exp Med. 1974 Oct 1;140(4):1068-84. doi: 10.1084/jem.140.4.1068.
7
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.针对恶病质素/肿瘤坏死因子的被动免疫可保护小鼠免受内毒素的致死作用。
Science. 1985 Aug 30;229(4716):869-71. doi: 10.1126/science.3895437.
8
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.一种用于检测人单核细胞细胞毒性因子/肿瘤坏死因子的高敏感性细胞系——WEHI 164克隆13。
J Immunol Methods. 1986 Dec 4;95(1):99-105. doi: 10.1016/0022-1759(86)90322-4.
9
The effect of lactoferrin on complement mediated modulation of immune complex size.
Immunol Lett. 1987 Apr;14(4):349-53. doi: 10.1016/0165-2478(87)90017-4.
10
Molecular cloning and expression of hybridoma growth factor in Escherichia coli.杂交瘤生长因子在大肠杆菌中的分子克隆与表达
J Immunol. 1987 Dec 15;139(12):4116-21.
Zotero 插件