Donnenfeld A E, Librizzi R J, Weiner S, Bolognese R J
Department of Obstetrics and Gynaecology, Pennsylvania Hospital, Philadelphia 19107.
Br J Obstet Gynaecol. 1993 Sep;100(9):826-7. doi: 10.1111/j.1471-0528.1993.tb14307.x.
To determine the incidence of fetal aneuploidy in women who had unsuccessful chorionic villus sampling (CVS) procedures.
Retrospective study.
Pennsylvania Hospital, Philadelphia, Pennsylvania, USA.
Two thousand six hundred and sixty-eight women who underwent chorionic villus sampling, in 78 (2.9%) of whom villi could not be obtained.
Sixty-nine of 78 (88%) women who had an unsuccessful CVS procedure underwent a subsequent amniocentesis later in the same pregnancy.
The incidence of aneuploidy identified from amniotic fluid chromosome analysis in the 69 women who had an unsuccessful CVS procedure compared to the frequency of aneuploidy in women having a successful CVS procedure.
Of the 69 women who underwent a post-CVS amniocentesis because of failure to obtain chorionic villi, six aneuploid pregnancies were identified (8.7%). The frequency of aneuploidy in the 2590 successfully sampled CVS patients was 2.5%. This difference was statistically significant (P = 0.009) by Fisher's exact test (two-tailed).
Women having an unsuccessful CVS procedure should be informed that they may be at increased risk for carrying an aneuploid fetus.
确定绒毛取样（CVS）操作失败的女性胎儿非整倍体的发生率。
回顾性研究。
美国宾夕法尼亚州费城的宾夕法尼亚医院。
2668名接受绒毛取样的女性，其中78名（2.9%）未能获取绒毛。
78名CVS操作失败的女性中，69名（88%）在同一孕期随后接受了羊膜腔穿刺术。
69名CVS操作失败的女性羊水染色体分析确定的非整倍体发生率，与CVS操作成功的女性中非整倍体发生率相比较。
69名因未能获取绒毛而在CVS术后接受羊膜腔穿刺术的女性中，确诊6例非整倍体妊娠（8.7%）。2590例CVS取样成功的患者中非整倍体发生率为2.5%。通过Fisher精确检验（双侧），这种差异具有统计学意义（P = 0.009）。
应告知CVS操作失败的女性，她们怀有非整倍体胎儿的风险可能会增加。
