编码谷氨酸脱羧酶（GAD65）的小鼠cDNA的克隆与序列分析。
Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65).
作者信息
Lee D S, Tian J, Phan T, Kaufman D L
机构信息
Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles 90024-1759.
出版信息
Biochim Biophys Acta. 1993 Oct 19;1216(1):157-60. doi: 10.1016/0167-4781(93)90056-j.
PMID:8218409
Abstract
We report the cloning and cDNA sequence of murine GAD65. Murine GAD65 is comprised of 585 amino acids and shares a high degree of homology with human and rat GAD65, with most divergences occurring near their amino-termini. The murine GAD65 sequence will allow evaluation of the role of this gene in murine neurogenetic and autoimmune diseases.
摘要
我们报道了小鼠GAD65的克隆及cDNA序列。小鼠GAD65由585个氨基酸组成，与人类和大鼠的GAD65具有高度同源性，大部分差异出现在其氨基末端附近。小鼠GAD65序列将有助于评估该基因在小鼠神经遗传性疾病和自身免疫性疾病中的作用。
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