Dore F, Bonfigli S, Gaviano E, Pardini S, Cianciulli P, Papa G, Longinotti M
Institute of Hematology and Endocrinology, University of Sassari, Italy.
Ann Hematol. 1993 Oct;67(4):183-6. doi: 10.1007/BF01695865.
Serum concentrations of erythropoietin (EPO) were determined by immunoassay in 45 patients with thalassemia intermedia (TI). The mean serum level of EPO was significantly higher in the thalassemic patients than in the controls, but transfused subjects had lower pretransfusional serum concentrations of EPO than untransfused ones. An inverse relationship between the serum values of EPO and total hemoglobin was observed only in the untransfused thalassemic patients. These data suggest that in TI, even a low transfusional regimen may cause a decrease in serum concentration of EPO, independent of the level of total Hb.
采用免疫分析法测定了45例中间型地中海贫血（TI）患者的血清促红细胞生成素（EPO）浓度。地中海贫血患者的血清EPO平均水平显著高于对照组，但接受输血的患者输血前血清EPO浓度低于未输血患者。仅在未输血的地中海贫血患者中观察到EPO血清值与总血红蛋白之间呈负相关。这些数据表明，在中间型地中海贫血中，即使是低输血方案也可能导致血清EPO浓度降低，而与总血红蛋白水平无关。
