李斯特菌细胞壁组分。体外佐剂活性的表征。
Listeria cell wall fraction. Characterization of in vitro adjuvant activity.
作者信息
Schuffler C, Campbell P A
出版信息
Immunology. 1976 Aug;31(2):323-9.
Abstract
We have previously described a crude cell wall fraction of Listeria monocytogenes (LCWF) which induces resistance to listeria infection in mice, is a murine B-cell mitogen and is an immunological adjuvant. Data reported here show that LCWF, which is effective over a wide dose range, exerts its adjuvant action on early events in the induction of an immune response. Moreover, LCWF stimulates nonadherent cells to respond to sheep red cells when adherent cells are severely depleted or absent, suggesting that LCWF can therefore act directly on lymphocytes present within the non-adherent population.
摘要
我们之前曾描述过一种单核细胞增生李斯特菌的粗制细胞壁组分（LCWF），它能诱导小鼠对李斯特菌感染产生抗性，是一种鼠B细胞促有丝分裂原，也是一种免疫佐剂。此处报告的数据表明，在很宽剂量范围内都有效的LCWF，对免疫应答诱导过程中的早期事件发挥其佐剂作用。此外，当贴壁细胞严重耗竭或不存在时，LCWF能刺激非贴壁细胞对绵羊红细胞作出反应，这表明LCWF因此可以直接作用于非贴壁群体中的淋巴细胞。
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