Nevalainen T J, Losacker W
Department of Pathology, University of Turku, Finland.
J Infect. 1997 Nov;35(3):251-2. doi: 10.1016/s0163-4453(97)92966-2.
Group II phospholipase A2 is an enzyme involved in the pathologies of various inflammatory diseases, including infections. We measured the concentration of group II phospholipase A2 in sera of 49 patients suffering from dengue, virus serotype 3, during a recent epidemic in The Cook Islands. Group II phospholipase A2 concentrations were elevated above the normal level in 90% of the patients. There was a significant negative correlation between group II phospholipase A2 levels and platelet counts. It was concluded that dengue virus infection causes a generalized inflammatory reaction and acute phase response. Determination of serum group II phospholipase A2 level gives useful information for assessing the severity of viral infections, including dengue.
II 型磷脂酶 A2 是一种参与包括感染在内的多种炎症性疾病病理过程的酶。在库克群岛最近一次登革热 3 型病毒流行期间，我们测量了 49 例登革热患者血清中 II 型磷脂酶 A2 的浓度。90% 的患者 II 型磷脂酶 A2 浓度高于正常水平。II 型磷脂酶 A2 水平与血小板计数之间存在显著负相关。得出的结论是，登革热病毒感染会引起全身性炎症反应和急性期反应。测定血清 II 型磷脂酶 A2 水平可为评估包括登革热在内的病毒感染的严重程度提供有用信息。
