Engerman R L, Kern T S, Garment M B
Department of Ophthalmology, University of Wisconsin, Madison 53706.
J Diabetes Complications. 1993 Oct-Dec;7(4):241-5.
Capillary basement membrane thickening has been compared in retina, renal glomerulus, and leg muscle of dogs alloxan-diabetic 5 years and dogs experimentally galactosemic 5 years, and the effects of inhibition of aldose reductase have been examined. Basement membrane in each site became thickened as a result of either galactosemia or diabetes, but showed appreciable variation among the sites. The thickening of basement membrane in retina and muscle of galactosemic animals was similar in quantity and appearance to that seen in the diabetics, notwithstanding large differences between the two animal models with respect to tissue polyol concentrations and nonenzymatic glycation of hemoglobin and plasma protein. Aldose reductase inhibition was without influence on capillary basement membrane thickening in each tissue from dogs diabetic or galactosemic 5 years, despite substantial polyol path inhibition.
对患四氧嘧啶糖尿病5年的犬以及实验性半乳糖血症5年的犬的视网膜、肾小球和腿部肌肉中的毛细血管基底膜增厚情况进行了比较，并研究了醛糖还原酶抑制作用的效果。由于半乳糖血症或糖尿病，每个部位的基底膜都变厚，但各部位之间存在明显差异。半乳糖血症动物视网膜和肌肉中基底膜的增厚在数量和外观上与糖尿病动物相似，尽管这两种动物模型在组织多元醇浓度以及血红蛋白和血浆蛋白的非酶糖基化方面存在很大差异。尽管多元醇途径受到显著抑制，但醛糖还原酶抑制对患糖尿病或半乳糖血症5年的犬的每个组织中的毛细血管基底膜增厚没有影响。
