Yamamoto M, Mogaki M, Matsuda M, Matsumoto Y
First Department of Surgery, Yamanashi Medical College, Japan.
Surg Today. 1993;23(9):830-5. doi: 10.1007/BF00311629.
The clinical course of a 68-year-old male with HCC is herein reported. In addition to two tumor nodules detected preoperatively, the resected surgical specimen disclosed macroscopically invisible tumor-cell clusters as well as intrahepatic metastatic foci. These clusters had no clear border and were more basophilic with small-sized cells, high cellularity, and a higher nuclear/cytoplasm ratio, which was suggestive of early HCC with a form of de novo occurrence. The postoperative course, characterized by an early recurrence of small nodules in the remnant liver suggested the presence of a similar invisible tumor mixture at the time of operation. This case can thus be regarded as a prototype of the multifocal recurrence type.
本文报告了一名68岁肝癌男性患者的临床病程。除术前检测到的两个肿瘤结节外，切除的手术标本在宏观上还发现了不可见的肿瘤细胞簇以及肝内转移灶。这些细胞簇没有清晰的边界，细胞较小，嗜碱性更强，细胞密度高，核质比更高，提示为新发形式的早期肝癌。术后病程以残余肝内小结节早期复发为特征，提示手术时存在类似的不可见肿瘤混合物。因此，该病例可被视为多灶复发类型的一个典型例子。
