[大黄对大鼠实验性糖尿病肾肥大和超滤过的影响]
[Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat].
作者信息
Yang J W, Li L S
机构信息
Institutes of Nephrology, Jingling Hospital, Nanjing.
出版信息
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 May;13(5):286-8, 261-2.
Renal hypertrophy and elevated glomerular filtration rate (GFR) appeared in early stage of diabetic nephropathy (DN). In order to investigate the effect of Rheum officinale (RO) on the renal hypertrophy, streptozotocin induced diabetic rats with moderate hyperglycemia were divided into two groups, receiving RO (RO-DN) or not (DN), and one group of non-diabetic control (C) was set up. At the 28th day, DN group exhibited heavier kidney weight (+61%), more protein (+133%) and DNA (+94%) contents in the kidney and higher GFR (+94%) than the control. RO-DN rats showed much less above mentioned changes. In addition, lipid abnormalities were ameliorated in RO-DN group. This result suggest that RO is beneficial to the diabetes in terms of renal hypertrophy and GFR changes at early stage and is recommended in the treatment of diabetic nephropathy.
肾肥大和肾小球滤过率（GFR）升高出现在糖尿病肾病（DN）的早期。为了研究大黄对肾肥大的影响，将链脲佐菌素诱导的中度高血糖糖尿病大鼠分为两组，一组给予大黄（RO-DN组），另一组不给予大黄（DN组），并设立一组非糖尿病对照组（C组）。在第28天，DN组的肾脏重量比对照组更重（增加61%），肾脏中的蛋白质含量（增加133%）和DNA含量（增加94%）更高，GFR也更高（增加94%）。RO-DN组大鼠上述变化要少得多。此外，RO-DN组的脂质异常得到改善。这一结果表明，大黄在早期肾肥大和GFR变化方面对糖尿病有益，推荐用于糖尿病肾病的治疗。
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