Christensen S T
Department of Anatomy and Cytology, University of Odense, Denmark.
Cell Biol Int. 1993 Sep;17(9):833-7. doi: 10.1006/cbir.1993.1145.
The presence of 10(-6) M bovine insulin in chemically defined nutrient medium prevented cell death and improved cell proliferation of the ciliate Tetrahymena pyriformis when inoculated at low initial cell density. The action of insulin was found to be restricted to the 22-30 fragment of the B-chain. These results suggest that small peptides are involved in regulation of cell survival and cell proliferation in Tetrahymena pyriformis.
