Dinneen M D, Fitzpatrick M M, Godley M L, Dicks-Mireaux C M, Ransley P G, Fernando O N, Trompeter R S, Duffy P G
Department of Paediatric Urology, Hospital for Sick Children, London.
Br J Urol. 1993 Sep;72(3):359-63. doi: 10.1111/j.1464-410x.1993.tb00733.x.
Seven boys (mean age 38 months) with posterior urethral valves underwent renal transplantation between June 1988 and August 1991. Urodynamic studies were performed before transplantation in 6/7 patients. In 4 the investigation indicated bladders of capacity and compliance which were deemed suitable for transplantation. Two patients had poorly compliant bladders; one of these underwent bladder augmentation before engraftment and the other proceeded to transplantation without bladder surgery. Six patients have functioning renal allografts with a mean follow-up of 1.3 years and a mean plasma creatinine of 51.6 mumol/l. Mean glomerular filtration rate (ml/min/1.73 m2 SA) 6 months after transplantation was 76.8 and at 1 year it was 84.5. In one patient early rejection was followed by transplant nephrectomy. Careful pre-operative evaluation is mandatory for a successful outcome of renal transplantation in young boys with posterior urethral valves.
1988年6月至1991年8月期间，7名患有后尿道瓣膜的男孩（平均年龄38个月）接受了肾移植。7例患者中有6例在移植前进行了尿动力学研究。4例检查显示膀胱容量和顺应性适合移植。2例患者膀胱顺应性差；其中1例在植入前进行了膀胱扩大术，另1例未进行膀胱手术直接进行了移植。6例患者的同种异体肾移植功能良好，平均随访1.3年，平均血浆肌酐为51.6μmol/L。移植后6个月平均肾小球滤过率（ml/min/1.73 m²体表面积）为76.8，1年时为84.5。1例患者早期排斥反应后进行了移植肾切除术。对于患有后尿道瓣膜的年轻男孩，肾移植成功的结果必须进行仔细的术前评估。
