Cravo S L, Morrison S F
Department of Physiology, Escola Paulista de Medicina, Sao Paulo, Brazil.
Brain Res. 1993 Sep 3;621(1):133-6. doi: 10.1016/0006-8993(93)90308-a.
The caudal ventrolateral medulla (CVLM) contains neurons that are essential for the elaboration of the sympathoinhibitory effects of baroreceptor afferent stimulation. To determine if neurons in the CVLM also mediate a tonic inhibition of sympathetic nerve activity (SNA), we examined the effects of lesioning CVLM neurons in baroreceptor-denervated rats. The sustained increases in both arterial pressure (AP; 40 mmHg) and splanchnic SNA (200%) indicate that the discharge of neurons in the CVLM maintains a tonic sympathoinhibition that contributes significantly to the maintenance of normotensive levels of SNA and AP.
延髓尾端腹外侧区（CVLM）包含一些神经元，这些神经元对于阐述压力感受器传入刺激的交感抑制作用至关重要。为了确定CVLM中的神经元是否也介导对交感神经活动（SNA）的紧张性抑制，我们研究了损毁压力感受器去神经大鼠的CVLM神经元的作用。动脉血压（AP；升高40 mmHg）和内脏SNA（升高200%）的持续升高表明，CVLM中神经元的放电维持着一种紧张性交感抑制，这对维持SNA和AP的正常血压水平有显著作用。
