抗原诱导小鼠B细胞上IgM和IgD样受体的共帽化。
Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.
作者信息
Goding J W, Layton J E
出版信息
J Exp Med. 1976 Sep 1;144(3):852-7. doi: 10.1084/jem.144.3.852.
Abstract
Double fluorescence studies indicated that most mature lymphocytes of 11-52-wk-old mice possess both IgM and IgD-like surface immunoglobulins, while spleen cells from neonatal mice possess surface IgM only. These molecules cap independently with class-specific antisera, but co-cap when capping is induced by antigen. It is proposed that the two heavy chains on individual lymphocytes possess similar or identical antigen-combining sites.
摘要
双重荧光研究表明，11至52周龄小鼠的大多数成熟淋巴细胞同时拥有IgM和IgD样表面免疫球蛋白，而新生小鼠的脾细胞仅拥有表面IgM。这些分子能与类特异性抗血清独立形成帽，但在抗原诱导形成帽时会共同形成帽。有人提出单个淋巴细胞上的两条重链拥有相似或相同的抗原结合位点。
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Monospecificity of bone marrow-derived lymphocytes.骨髓来源淋巴细胞的单特异性
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Immunoglobulin D as a lymphocyte receptor.作为淋巴细胞受体的免疫球蛋白D
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Cell surface immunoglobulin. X. Identification of an IgD-like molecule on the surface of murine splenocytes.细胞表面免疫球蛋白。X. 小鼠脾细胞表面一种类IgD分子的鉴定。
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Candidate for immunoglobulin D present on murine B lymphocytes.鼠B淋巴细胞上免疫球蛋白D的候选物。
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Same idiotype of B-lymphocyte membrane IgD and IgM. Formal evidence for monoclonality of chronic lymphocytic leukemia cells.B淋巴细胞膜IgD和IgM具有相同的独特型。慢性淋巴细胞白血病细胞单克隆性的确切证据。
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