Goding J W, Layton J E
J Exp Med. 1976 Sep 1;144(3):852-7. doi: 10.1084/jem.144.3.852.
Double fluorescence studies indicated that most mature lymphocytes of 11-52-wk-old mice possess both IgM and IgD-like surface immunoglobulins, while spleen cells from neonatal mice possess surface IgM only. These molecules cap independently with class-specific antisera, but co-cap when capping is induced by antigen. It is proposed that the two heavy chains on individual lymphocytes possess similar or identical antigen-combining sites.
双重荧光研究表明,11至52周龄小鼠的大多数成熟淋巴细胞同时拥有IgM和IgD样表面免疫球蛋白,而新生小鼠的脾细胞仅拥有表面IgM。这些分子能与类特异性抗血清独立形成帽,但在抗原诱导形成帽时会共同形成帽。有人提出单个淋巴细胞上的两条重链拥有相似或相同的抗原结合位点。