[An experimental observation of effect of tetrandrine on pulmonary dysfunction in rabbit model of smoke inhalation injury].

A rabbit model with severe smoke inhalation injury was adopted to observe the effect of tetrandrine, a calcium antagonist, on pulmonary dysfunction after smoke inhalation during 24 hours post injury. It was found that tetrandrine could decrease the permeability of pulmonary and tracheal vascular permeability (p < 0.01), reduce lung edema and improve the function of respiration. These results imply that tetrandrine might be used in the treatment of inhalation injury.