Mochizuki S, Smith C I, Hällgren R, Hammarström L
Department of Clinical Immunology, Huddinge Hospital, Sweden.
Clin Exp Immunol. 1993 Nov;94(2):334-6. doi: 10.1111/j.1365-2249.1993.tb03453.x.
The presence of serum IgM and IgG antibodies against IgA is common among individuals with IgA deficiency. The route of immunization is still unknown, but it is possible that immunization occurs through the gut. We analysed anti-IgA antibody production in gastrointestinal lavage, saliva and breast milk from patients with IgA deficiency. In no case was there any evidence of local production of anti-IgA antibodies. Immunization may thus be due to exposure to endogenous IgA and therefore represent a 'true' autoimmune phenomenon which may possibly be involved in the pathogenesis of the disease.
在IgA缺乏的个体中，存在针对IgA的血清IgM和IgG抗体是很常见的。免疫途径尚不清楚，但有可能是通过肠道进行免疫。我们分析了IgA缺乏患者的胃肠灌洗液、唾液和母乳中抗IgA抗体的产生情况。在任何情况下，都没有证据表明存在抗IgA抗体的局部产生。因此，免疫可能是由于接触内源性IgA引起的，因此代表一种“真正的”自身免疫现象，这可能参与了该疾病的发病机制。
